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Background and aims The published data about the efficacy of the intercellular adhesion molecule-1 (ICAM-1) antisense… Expand The antisense ICAM‐1 inhibitor alicaforsen has been studied in four phase 2 studies in ulcerative colitis (UC). Recruited… Expand BACKGROUND & AIMS
The aim of this study was to compare the safety and efficacy of alicaforsen, a first-generation antisense… Expand Alicaforsen is an antisense oligonucleotide inhibitor of intercellular adhesion molecule 1 protein expression with activity in… Expand Alicaforsen is a phosphorothioate‐modified antisense oligodeoxynucleotide designed to sequence‐specifically reduce intercellular… Expand Background : Pouchitis is the major long‐term complication of ileal pouch‐anal anastomosis for ulcerative colitis. The incidence… Expand Objective: To evaluate the safety and efficacy of an enema formulation of alicaforsen, an antisense inhibitor of intercellular… Expand Background and aims: To evaluate the safety and efficacy of the intercellular adhesion molecule 1 (ICAM-1) antisense… Expand Background and aims : To evaluate the safety, pharmacokinetics and clinical efficacy of the intercellular adhesion molecule‐1… Expand Alicaforsen (ISIS-2302) is an RNase H-dependent antisense inhibitor of the intercellular adhesion molecule ICAM-1 under… Expand