alicaforsen
National Institutes of Health
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Specific blockade of the endothelial ligands intercellular adhesion molecule-1 [ICAM-1] and mucosal addressin cell adhesion…
ABSTRACT Introduction: Intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein of the immunoglobulin family…
Background and aims The published data about the efficacy of the intercellular adhesion molecule-1 (ICAM-1) antisense…
Alicaforsen is an antisense oligonucleotide inhibitor of intercellular adhesion molecule 1 protein expression with activity in…
Alicaforsen is a phosphorothioate‐modified antisense oligodeoxynucleotide designed to sequence‐specifically reduce intercellular…
Background : Pouchitis is the major long‐term complication of ileal pouch‐anal anastomosis for ulcerative colitis. The incidence…
Objective: To evaluate the safety and efficacy of an enema formulation of alicaforsen, an antisense inhibitor of intercellular…
Background and aims: To evaluate the safety and efficacy of the intercellular adhesion molecule 1 (ICAM-1) antisense…
Background and aims : To evaluate the safety, pharmacokinetics and clinical efficacy of the intercellular adhesion molecule‐1…
Alicaforsen (ISIS-2302) is an RNase H-dependent antisense inhibitor of the intercellular adhesion molecule ICAM-1 under…