Phosphorothioate Oligonucleotides

Known as: Oligonucleotides, Phosphorothioate, Phosphorothioate Oligonucleotide, Phosphorothioate Oligonucleotides [Chemical/Ingredient] 
Modified oligonucleotides in which one of the oxygens of the phosphate group is replaced with a sulfur atom.
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
The scarring response is an important factor in many diseases throughout the body. In addition, it is a major problem in… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE To evaluate the pharmacokinetics and toxicity of an antisense oligonucleotide targeting bcl-2 in patients with non… (More)
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Highly Cited
2000
Highly Cited
2000
Angiogenesis plays a key role in tumor growth and metastasis. The transforming growth factor alpha (TGF-alpha)-epidermal growth… (More)
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1998
1998
Systemic administration of ISIS 2302, a 20-mer antisense phosphorothioate oligonucleotide targeting human intercellular adhesion… (More)
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1996
1996
Methods are presented for the extraction of phosphorothioate oligonucleotides from human plasma to permit quantitation by… (More)
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Highly Cited
1994
Highly Cited
1994
To examine the functions of ERM family members (ezrin, radixin, and moesin), mouse epithelial cells (MTD-1A cells) and thymoma… (More)
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Highly Cited
1993
Highly Cited
1993
"Uniformly" modified phosphodiester or phosphorothioate oligonucleotides incorporating 2'-deoxy-2'-fluoroadenosine, -guanosine… (More)
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Highly Cited
1991
Highly Cited
1991
We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide… (More)
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Highly Cited
1990
Highly Cited
1990
Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how… (More)
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Highly Cited
1988
Highly Cited
1988
We have recently shown that phosphorothioate (PS) oligodeoxynucleotide (ODN) analogs, unlike their normal congeners, exhibit… (More)
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