Skip to search formSkip to main contentSkip to account menu

Phosphorothioate Oligonucleotides

Known as: Oligonucleotides, Phosphorothioate, Phosphorothioate Oligonucleotide, Phosphorothioate Oligonucleotides [Chemical/Ingredient] 
Modified oligonucleotides in which one of the oxygens of the phosphate group is replaced with a sulfur atom.
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (7)

ISIS 2503ISIS104838SPC3649TPI ASM8
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100
The pharmacokinetics of a 2′-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting human apolipoprotein B-100 (apoB… 
Highly Cited
2000
Highly Cited
2000
Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma.
PURPOSE To evaluate the pharmacokinetics and toxicity of an antisense oligonucleotide targeting bcl-2 in patients with non… 
Highly Cited
1998
Highly Cited
1998
Self-assembly of polyamine-poly(ethylene glycol) copolymers with phosphorothioate oligonucleotides.
The cationic copolymers for DNA delivery were synthesized by conjugating poly(ethylene glycol) (PEG) and polyamines: polyspermine… 
Review
1997
Review
1997
In vivo studies with antisense oligonucleotides.
Highly Cited
1996
Highly Cited
1996
Quantitation of phosphorothioate oligonucleotides in human plasma.
Methods are presented for the extraction of phosphorothioate oligonucleotides from human plasma to permit quantitation by… 
Highly Cited
1994
Highly Cited
1994
Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.
Biodistribution and metabolism of oligonucleotides were determined using a 3H-labeled 20-nucleotide phosphodiester and its… 
Highly Cited
1994
Highly Cited
1994
Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey.
Rapid intravenous infusion of GEM 91, a 25-mer phosphorothioate oligonucleotide complementary to the gag site of HIV, in the… 
Highly Cited
1994
Highly Cited
1994
Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.
In response to inflammatory stimuli, expression of a group of proteins that bind circulating leukocytes (endothelial-leukocyte… 
Highly Cited
1993
Highly Cited
1993
Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.
5'-TTGCTTCCATCTTCCTCGTC-3' (ISIS 2105) is a phosphorothioate oligodeoxynucleotide currently being evaluated as an intralesional… 
Highly Cited
1992
Highly Cited
1992
Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology.
Phosphorothioate oligodeoxycytidine (S-dCn) was used as a model compound to examine the impact of the number of phosphorothioate… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)