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adefovir

Known as: 9-(2-phosphonomethoxyethyl)adenine, Phosphonylmethoxyethyl-a, 9-(2-phophonylmethoxyethyl)adenine 
A nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human… 
National Institutes of Health

Related topics

Related topics

15 relations
Adefovir:Susc:Pt:Isolate:OrdQnDrug AllergyHepatitis BNucleoside Analogs

Broader (5)

AdenineAntiviral AgentsOrganophosphonatesReverse Transcriptase Inhibitors

Narrower (2)

Hepseraadefovir dipivoxil

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage.
Nucleoside-based analogues are mainstays in the treatment of cancer, viral infections, and inflammatory diseases. Recent studies… 
Highly Cited
2001
Highly Cited
2001
Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model.
Highly Cited
2000
Highly Cited
2000
Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS…
This study compared antiretroviral activity among 6 "salvage" therapy regimens. The study was a prospective, randomized, 2x3… 
Highly Cited
1999
Highly Cited
1999
Identification and Rapid Quantification of Early- and Late-Lytic Human Herpesvirus 8 Infection in Single Cells by Flow Cytometric Analysis: Characterization of Antiherpesvirus Agents
ABSTRACT Human herpesvirus 8 (HHV-8) infection is associated with Kaposi’s sarcoma, primary effusion lymphoma (PEL), and… 
Highly Cited
1996
Highly Cited
1996
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
The (S)- and (R)-enantiomers of 9-(2-phosphonylmethoxypropyl) derivatives of adenine (PMPA) and 2,6-diaminopurine (PMPDAP) were… 
Highly Cited
1996
Highly Cited
1996
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro
9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), an acyclic nucleoside phosphonate analog, is active against several retroviruses and… 
Highly Cited
1995
Highly Cited
1995
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine
Cloned variants of human immunodeficiency virus type 1 that contain the K65R mutation in reverse transcriptase have previously… 
Highly Cited
1993
Highly Cited
1993
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates
Bis(pivaloyloxymethyl) [bis(pom)] derivatives of various acyclic nucleoside phosphonates--9-(2-phosphonylmethoxyethyl)adenine… 
Highly Cited
1993
Highly Cited
1993
Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process.
Highly Cited
1989
Highly Cited
1989
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
The murine model of acquired immunodeficiency disease was used to evaluate both the antiretroviral and antiherpetic activities of… 
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