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abacavir

Known as: 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, ABC, {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol 
A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (6)

1592U89EpzicomTriumeqTrizivir
Abacavir:ACnc:Pt:Ser/Plas:QnAbacavir:Susc:Pt:Isolate:OrdQnAbacavir:Susc:Pt:Isolate:OrdQn:GenotypingAcquired Immunodeficiency Syndrome

Broader (5)

Anti-HIV AgentsAntiviral AgentsDeoxyribonucleosidesDideoxynucleosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Detergent-free purification of ABC (ATP-binding-cassette) transporters.
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the… 
Review
2011
Review
2011
Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.
Highly Cited
2009
Highly Cited
2009
Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine
The non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is directly conjugated by the UDP-glucuronosyltransferase (UGT… 
Highly Cited
2005
Highly Cited
2005
Clinical and immunogenetic correlates of abacavir hypersensitivity
A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients… 
Highly Cited
2005
Highly Cited
2005
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.
Highly Cited
2004
Highly Cited
2004
Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults.
BACKGROUND Zidovudine, lamivudine, and efavirenz comprise a highly effective and well-tolerated triple regimen for antiretroviral… 
Review
2002
Review
2002
Genetic defects in hepatobiliary transport.
Highly Cited
2000
Highly Cited
2000
HIV-1 reverse transcriptase (RT) genotype and susceptibility to RT inhibitors during abacavir monotherapy and combination therapy
ObjectiveTo examine changes in HIV-1 susceptibility (genotype and phenotype) during an initial abacavir monotherapy phase… 
Highly Cited
2000
Highly Cited
2000
Abacavir
SummaryAbstractAbacavir is a carbocyclic 2′-deoxyguanosine nucleoside analogue. It is metabolised intracellularly to a 2… 
Highly Cited
1991
Highly Cited
1991
Evidence for a common molecular origin of the capsule gene loci in Gram‐negative bacteria expressing group II capsular polysaccharides
Capsular polysaccharides of Gram‐negative bacteria contribute to a large extent to the pathogenicity of these organisms. We show… 
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