abacavir

Known as: 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, ABC, {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol 
A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Long-term effects of abacavir (ABC)-lamivudine (3TC), compared with tenofovir (TDF)-emtricitabine (FTC) with efavirenz… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Abacavir/lamivudine and tenofovir/emtricitabine fixed-dose combinations are commonly used first-line antiretroviral… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND There are 2 once-daily, fixed-dose-combination, dual-nucleoside analogue tablets: tenofovir 300 mg-emtricitabine 200… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study… (More)
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Highly Cited
2005
Highly Cited
2005
Abacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective… (More)
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Highly Cited
2004
Highly Cited
2004
Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Abacavir, a human immunodeficiency virus-1 (HIV-1) nucleoside-analogue reverse transcriptase inhibitor, causes severe… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The use of abacavir--a potent HIV-1 nucleoside-analogue reverse-transcriptase inhibitor--is complicated by a… (More)
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Highly Cited
2002
Highly Cited
2002
Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case… (More)
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Highly Cited
2001
Highly Cited
2001
CONTEXT Abacavir, a nucleoside analogue, has demonstrated suppression of human immunodeficiency virus (HIV) replication alone and… (More)
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