Skip to search formSkip to main contentSkip to account menu

abacavir

Known as: 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, ABC, {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol 
A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (6)

1592U89EpzicomTriumeqTrizivir
Abacavir:ACnc:Pt:Ser/Plas:QnAbacavir:Susc:Pt:Isolate:OrdQnAbacavir:Susc:Pt:Isolate:OrdQn:GenotypingAcquired Immunodeficiency Syndrome

Broader (5)

Anti-HIV AgentsAntiviral AgentsDeoxyribonucleosidesDideoxynucleosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study
Review
2009
Review
2009
Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy.
BACKGROUND The use of fixed-dose combination nucleoside reverse-transcriptase inhibitors (NRTIs) with a nonnucleoside reverse… 
Highly Cited
2008
Highly Cited
2008
HLA-B*5701 screening for hypersensitivity to abacavir.
BACKGROUND Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study… 
Highly Cited
2008
Highly Cited
2008
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration
Review
2008
Review
2008
High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients.
BACKGROUND Although the human leukocyte antigen (HLA)-B*5701 is highly associated with a hypersensitivity reaction (HSR) to… 
Highly Cited
2006
Highly Cited
2006
Variability in the clinical pattern of cutaneous side‐effects of drugs with systemic symptoms: does a DRESS syndrome really exist?
Objective  To improve the definition of the various clinical patterns of patients with drug‐induced cutaneous side‐effects with… 
Highly Cited
2004
Highly Cited
2004
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong… 
Highly Cited
2004
Highly Cited
2004
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.
OBJECTIVE Abacavir, a human immunodeficiency virus-1 (HIV-1) nucleoside-analogue reverse transcriptase inhibitor, causes severe… 
Highly Cited
2002
Highly Cited
2002
Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
Highly Cited
2002
Highly Cited
2002
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)