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abacavir

Known as: 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, ABC, {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol 
A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (6)

1592U89EpzicomTriumeqTrizivir
Abacavir:ACnc:Pt:Ser/Plas:QnAbacavir:Susc:Pt:Isolate:OrdQnAbacavir:Susc:Pt:Isolate:OrdQn:GenotypingAcquired Immunodeficiency Syndrome

Broader (5)

Anti-HIV AgentsAntiviral AgentsDeoxyribonucleosidesDideoxynucleosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Detergent-free purification of ABC (ATP-binding-cassette) transporters.
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the… 
Highly Cited
2011
Highly Cited
2011
Drug hypersensitivity: pharmacogenetics and clinical syndromes.
Review
2009
Review
2009
Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy.
BACKGROUND The use of fixed-dose combination nucleoside reverse-transcriptase inhibitors (NRTIs) with a nonnucleoside reverse… 
Highly Cited
2007
Highly Cited
2007
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein.
Highly Cited
2005
Highly Cited
2005
Clinical and immunogenetic correlates of abacavir hypersensitivity
A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients… 
Highly Cited
2004
Highly Cited
2004
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong… 
Review
2004
Review
2004
Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection.
BACKGROUND Regimens containing three nucleoside reverse-transcriptase inhibitors offer an alternative to regimens containing… 
Highly Cited
2004
Highly Cited
2004
Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults.
BACKGROUND Zidovudine, lamivudine, and efavirenz comprise a highly effective and well-tolerated triple regimen for antiretroviral… 
Highly Cited
2000
Highly Cited
2000
Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography.
Highly Cited
1991
Highly Cited
1991
Evidence for a common molecular origin of the capsule gene loci in Gram‐negative bacteria expressing group II capsular polysaccharides
Capsular polysaccharides of Gram‐negative bacteria contribute to a large extent to the pathogenicity of these organisms. We show… 
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