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1592U89

 
National Institutes of Health

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2 relations

Broader (2)

abacavirabacavir sulfate

Papers overview

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Highly Cited
2000
Highly Cited
2000
Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group.
Abacavir (1592U89) is a nucleoside inhibitor of human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT). Resistance… Expand
Highly Cited
1999
Highly Cited
1999
Single-Dose Pharmacokinetics and Safety of Abacavir (1592U89), Zidovudine, and Lamivudine Administered Alone and in Combination in Adults with Human Immunodeficiency Virus Infection
ABSTRACT Abacavir (1592U89), a nucleoside reverse transcriptase inhibitor with in vitro activity against human immunodeficiency… Expand
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1998
1998
Nucleoside Analog 1592U89 and Human Immunodeficiency Virus Protease Inhibitor 141W94 Are Synergistic In Vitro
ABSTRACT The use of combinations of anti-human immunodeficiency virus (anti-HIV) agents targeted to different molecular targets… Expand
1998
1998
Combinaisons antivirales contenant le nucleoside carbocyclique 1592u89
L'invention concerne des combinaisons therapeutiques de (-)-(1S, 4R)-4-[2-amino-6- (cyclopropylamino)-9H-purin-9-yl] -2… Expand
Highly Cited
1997
Highly Cited
1997
1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity.
1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, is a carbocyclic nucleoside with… Expand
Highly Cited
1997
Highly Cited
1997
Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89.
The anabolism of 1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, a selective… Expand
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Highly Cited
1997
Highly Cited
1997
Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89.
The carbocyclic nucleoside 1592U89 is a selective inhibitor of the human immunodeficiency virus (HIV), targeting the reverse… Expand
Review
1996
Review
1996
An Efficient Asymmetric Approach to Carbocyclic Nucleosides: Asymmetric Synthesis of 1592U89, a Potent Inhibitor of HIV Reverse Transcriptase.
Carbocyclic nucleosides have been the focus of much recent attention in the development of new antitumor and antiviral… Expand
1996
1996
Zidovudine, synergistic combination of 1592u89 and 3tc or ftc
(57) Abstract: The present invention has an anti-HIV activity (1S, 4R) - cis -4- [2-amino-6- (cyclopropylamino) -9H- purin-9-yl… Expand
1996
1996
Combinaisons synergiques de zidovudine, 1592u89 et 3tc ou ftc
L'invention concerne des combinaisons therapeutiques de (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene… Expand
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