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ZEB2 wt Allele

Known as: KIAA0569, ZFX1B, ZFHX1B 
Human ZEB2 wild-type allele is located in the vicinity of 2q22 and is approximately 132 kb in length. This allele, which encodes zinc finger E-box… Expand
National Institutes of Health

Related topics

Related topics

9 relations
2q22Homo sapiensTranscriptional RegulationTranscriptional Repression
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Broader (1)

ZEB2 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
Epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair and cancer progression in adult… Expand
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Highly Cited
2010
Highly Cited
2010
Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels.
Aberrant DNA methylation and microRNA expression play important roles in the pathogenesis of pancreatic cancer. While… Expand
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Highly Cited
2008
Highly Cited
2008
Genome‐wide microRNA expression profiling in renal cell carcinoma: significant down‐regulation of miR‐141 and miR‐200c
We investigated expression profiles of microRNA (miRNA) in renal cell carcinoma [clear cell carcinomas (CCC) and chromophobe… Expand
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Highly Cited
2007
Highly Cited
2007
miR-200b mediates post-transcriptional repression of ZFHX1B.
MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their… Expand
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Highly Cited
2006
Highly Cited
2006
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
A critical event in the pathogenesis of invasive and metastatic cancer is E-cadherin loss of function. Renal clear cell carcinoma… Expand
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Highly Cited
2003
Highly Cited
2003
Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.
Recently, mutations in ZFHX1B, the gene that encodes Smad-interacting protein-1 (SIP1), were found to be implicated in the… Expand
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Highly Cited
2002
Highly Cited
2002
Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer.
Epithelial-mesenchymal transition (EMT) involving down-regulation of E-cadherin is thought to play a fundamental role during… Expand
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Highly Cited
2001
Highly Cited
2001
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
Transcriptional downregulation of E-cadherin appears to be an important event in the progression of various epithelial tumors… Expand
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Highly Cited
2001
Highly Cited
2001
Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease
Hirschsprung disease (HSCR) is sometimes associated with a set of characteristics including mental retardation, microcephaly, and… Expand
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Highly Cited
2001
Highly Cited
2001
Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease.
Hirschsprung disease (HD) has been described in association with microcephaly, mental retardation and characteristic facial… Expand
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