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ZEB2 wt Allele

Known as: KIAA0569, ZFX1B, ZFHX1B 
Human ZEB2 wild-type allele is located in the vicinity of 2q22 and is approximately 132 kb in length. This allele, which encodes zinc finger E-box… 
National Institutes of Health

Related topics

Related topics

9 relations
2q22Homo sapiensTranscriptional RegulationTranscriptional Repression

Broader (1)

ZEB2 gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
Epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair and cancer progression in adult… 
Highly Cited
2010
Highly Cited
2010
Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels.
Aberrant DNA methylation and microRNA expression play important roles in the pathogenesis of pancreatic cancer. While… 
Highly Cited
2008
Highly Cited
2008
Genome‐wide microRNA expression profiling in renal cell carcinoma: significant down‐regulation of miR‐141 and miR‐200c
We investigated expression profiles of microRNA (miRNA) in renal cell carcinoma [clear cell carcinomas (CCC) and chromophobe… 
Highly Cited
2007
Highly Cited
2007
miR-200b mediates post-transcriptional repression of ZFHX1B.
MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their… 
Highly Cited
2006
Highly Cited
2006
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
A critical event in the pathogenesis of invasive and metastatic cancer is E-cadherin loss of function. Renal clear cell carcinoma… 
Highly Cited
2003
Highly Cited
2003
Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.
Recently, mutations in ZFHX1B, the gene that encodes Smad-interacting protein-1 (SIP1), were found to be implicated in the… 
Highly Cited
2002
Highly Cited
2002
Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer.
Highly Cited
2001
Highly Cited
2001
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
Highly Cited
2001
Highly Cited
2001
Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease.
Hirschsprung disease (HD) has been described in association with microcephaly, mental retardation and characteristic facial… 
Highly Cited
2001
Highly Cited
2001
Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease
Hirschsprung disease (HSCR) is sometimes associated with a set of characteristics including mental retardation, microcephaly, and… 
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