• Publications
  • Influence
Frequency of small supernumerary marker chromosomes in prenatal, newborn, developmentally retarded and infertility diagnostics.
  • T. Liehr, A. Weise
  • Medicine
    International journal of molecular medicine
  • 1 May 2007
There is a strong need for a better genotype-phenotype correlation enabling better genetic counseling and no increased risk for the presence of sSMC was detected in ICSI-induced pregnancies.
Small supernumerary marker chromosomes (sSMC) in humans
An overview of small supernumerary marker chromosomes is presented, including the first attempt to address problems of nomenclature and their modes of formation, problems connected with mosaicism plus familial occurrence and a short review of the up-to-date approaches available for sSMC characterization.
Human male recombination maps for individual chromosomes.
The first (to the authors' knowledge) recombination maps for every autosome in the human male obtained by new immunofluorescence techniques followed by centromere-specific multicolor fluorescence in situ hybridization in human spermatocytes are presented.
Small supernumerary marker chromosomes – progress towards a genotype-phenotype correlation
The first draft of a basic genotype-phenotype correlation for sSMC for all human chromosomes apart from the chromosomes Y, 10, 11 and 13 is presented.
Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
Pre-differentiation of human MSCs from adipose tissue into hepatocyte-like cells in vitro facilitates long term functional hepatic integration in vivo.
Genome‐wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U‐CH1
The data suggest that tumor suppressor genes or mismatch repair genes and oncogenes might be involved in chordoma genesis and raised the first human chordoma cell line, U‐CH1, from a recurrence of a sacral chordoma.
Aneuploidy and Confined Chromosomal Mosaicism in the Developing Human Brain
The data indicates aneuploidization to be an additional pathological mechanism for neuronal genome diversification and an unexpected link between developmental chromosomal instability, intercellural/intertissular genome diversity and human brain diseases is suggested.
Complex chromosomal rearrangements: origin and meiotic behavior.
Despite the increasing understanding of the mechanisms involved in their genesis, CCRs arise as unique, complex events for which the genetic and reproductive counseling of carriers remains a challenge.