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ZAP70 wt Allele

Known as: Zeta-Chain (TCR) Associated Protein Kinase 70kDa wt Allele, SRK, ZAP-70 
Human ZAP70 wild-type allele is located within 2q12 and is approximately 26 kb in length. This allele, which encodes ZAP70 protein, plays a role in… 
National Institutes of Health

Related topics

Related topics

18 relations
2q12Cell Differentiation processCell ProliferationChronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Broader (1)

ZAP70 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
TULA‐family proteins: A new class of cellular regulators
Proteins of the UBASH3/STS/TULA family recently emerged as potent regulators of cellular functions. They are characterized by a… 
Highly Cited
2008
Highly Cited
2008
Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells
The reasons why immunoglobulin gene mutation status and expression of ZAP-70 and CD38 influence disease progression in chronic… 
2007
2007
Comparative analysis of flow cytometric techniques in assessment of ZAP-70 expression in relation to IgVH mutational status in chronic lymphocytic leukemia.
We compared 1 subjective and 5 objective flow cytometric methods to evaluate zeta-associated protein (ZAP-70) expression in… 
2006
2006
Dexamethasone induces rapid tyrosine-phosphorylation of ZAP-70 in Jurkat cells
2006
2006
An optimized whole blood method for flow cytometric measurement of ZAP‐70 protein expression in chronic lymphocytic leukemia
ZAP‐70 protein expression has been proposed as a marker for immunoglobulin heavy chain mutational status, which some studies have… 
2000
2000
Signaling via the T Cell Antigen Receptor Induces Phosphorylation of Stat1 on Serine 727*
The Stat1 transcription factor plays a pivotal role in both, the antiviral and antigrowth actions of interferons. Stat1 acquires… 
1998
1998
Prolactin stimulates phosphorylation of the human T-cell antigen receptor complex and ZAP-70 tyrosine kinase: a potential mechanism for its immunomodulation.
Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular… 
Highly Cited
1997
Highly Cited
1997
ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.
Activation-induced cell death (AICD) is initiated by the TCR-dependent up-regulation of Fas ligand (FasL) mRNA. The subsequently… 
Highly Cited
1996
Highly Cited
1996
Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.
Ligation of MHC class I-recognizing receptors on NK cells dramatically modulates their secretory and cytotoxic function. This… 
1995
1995
Regulation of Zap-70 by Src Family Tyrosine Protein Kinases in an Antigen-specific T-cell Line (*)
To further understand the interactions between Zap-70, Src family kinases, and other T-cell proteins, we have examined the… 
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