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ZAP70 wt Allele

Known as: Zeta-Chain (TCR) Associated Protein Kinase 70kDa wt Allele, SRK, ZAP-70 
Human ZAP70 wild-type allele is located within 2q12 and is approximately 26 kb in length. This allele, which encodes ZAP70 protein, plays a role in… 
National Institutes of Health

Related topics

Related topics

18 relations
2q12Cell Differentiation processCell ProliferationChronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Broader (1)

ZAP70 gene

Papers overview

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Review
2013
Review
2013
TULA‐family proteins: A new class of cellular regulators
Proteins of the UBASH3/STS/TULA family recently emerged as potent regulators of cellular functions. They are characterized by a… 
Highly Cited
2006
Highly Cited
2006
B lymphocytes in humans express ZAP‐70 when activated in vivo
ZAP‐70 is a protein tyrosine kinase initially found in T and NK cells. Recently, this important signaling element was detected in… 
2006
2006
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)
B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this… 
Highly Cited
2001
Highly Cited
2001
Distinct T Cell Developmental Consequences in Humans and Mice Expressing Identical Mutations in the DLAARN Motif of ZAP-701
The protein tyrosine kinase, ZAP-70, is pivotally involved in transduction of Ag-binding signals from the TCR required for T cell… 
Highly Cited
1999
Highly Cited
1999
Degradation of ZAP-70 following antigenic stimulation in human T lymphocytes: role of calpain proteolytic pathway.
T cell activation by the specific Ag results in dramatic changes of the T cell phenotype that include a rapid and profound down… 
Highly Cited
1998
Highly Cited
1998
Nocodazole Inhibits Signal Transduction by the T Cell Antigen Receptor*
The potential role of the cytoskeleton in signaling via the T cell antigen receptor (TCR) was investigated using pharmacological… 
Highly Cited
1997
Highly Cited
1997
ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.
Activation-induced cell death (AICD) is initiated by the TCR-dependent up-regulation of Fas ligand (FasL) mRNA. The subsequently… 
Highly Cited
1996
Highly Cited
1996
Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.
Ligation of MHC class I-recognizing receptors on NK cells dramatically modulates their secretory and cytotoxic function. This… 
Highly Cited
1995
Highly Cited
1995
Interactions between the Protein-tyrosine Kinase ZAP-70, the Proto-oncoprotein Vav, and Tubulin in Jurkat T Cells (*)
Two molecules involved in signal transduction via the T cell antigen receptor, namely the protein-tyrosine kinase ZAP-70 and the… 
Review
1994
Review
1994
Role of tyrosine kinases in lymphocyte activation.
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