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Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System12
The recent description of virus-induced fish IFNs has raised questions about the evolution of this complex antiviral system. Identification of the receptor of the zebrafish virus-induced IFN (zIFN)Expand
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Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.
Polyamines are small, positively charged molecules derived from ornithine and synthesized through an intricately regulated enzymatic pathway. Within cells, they are abundant and play several roles inExpand
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A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish
BackgroundIn mammals, the members of the tripartite motif (TRIM) protein family are involved in various cellular processes including innate immunity against viral infection. Viruses exert strongExpand
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A novel subset of adult γδ thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire
We have characterized the function, phenotype, ontogenic development, and T cell receptor (TCR) repertoire of a subpopulation of γδ thymocytes, initially defined by expressing low levels of Thy‐1,Expand
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Transient infection of the zebrafish notochord with E. coli induces chronic inflammation
Zebrafish embryos and larvae are now well-established models in which to study infectious diseases. Infections with non-pathogenic Gram-negative Escherichia coli induce a strong and reproducibleExpand
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The Peculiar Characteristics of Fish Type I Interferons
Antiviral type I interferons (IFNs) have been discovered in fish. Genomic studies revealed their considerable number in many species; some genes encode secreted and non-secreted isoforms. Based onExpand
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Neutrophils use superoxide to control bacterial infection at a distance
Understanding the roles of neutrophils and macrophages in fighting bacterial infections is a critical issue in human pathologies. Although phagocytic killing has been extensively studied, little isExpand
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In vivo analysis of zebrafish innate immunity.
Among vertebrate model species, the zebrafish embryo combines at an unprecedented level optical accessibility with easy genetic manipulation. As such, it is gaining recognition as a powerful model toExpand
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Through the looking glass: witnessing host-virus interplay in zebrafish.
Host-pathogen interactions can be very complex at all scales; understanding organ- or organism-level events require in vivo approaches. Besides traditional host models such as mice, the zebrafishExpand
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Single-cell transcriptional analysis reveals ILC-like cells in zebrafish
Analyses of immune cells in rag1-deficient zebrafish led to the discovery of innate lymphoid cells in teleosts. Fishing for ILCs in zebrafish To date, most studies on innate lymphoid cells (ILCs)Expand
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