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YM-44778

National Institutes of Health

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Spiro Compounds

Papers overview

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2005
2005
Effect of neurokinins on canine prostate cell physiology
Sensory peptide neurotransmitters have been implicated as significant regulators of prostate growth. This study was designed to… 
2002
2002
Effect of YM-44781, YM-44778 and YM-49598, Novel Tachykinin Antagonists, in a Drug-Induced Bladder Contraction Model
The radioligand binding profiles and in vivo pharmacological characteristics of YM-44781, YM-44778 and YM-49598, novel non… 
1998
1998
Spiro-substituted piperidines as neurokinin receptor antagonists. III. Synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and evaluation of…
To discover a novel NK1-NK2 dual antagonist, we have synthesized a series of spiro-substituted piperidines utilizing YM-35375 as… 
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