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Effect of YM-44781, YM-44778 and YM-49598, Novel Tachykinin Antagonists, in a Drug-Induced Bladder Contraction Model
In an in vivo rat model, a drug-induced bladder contraction model, antagonism of the contractions produced by the selective NK<sub>2</sub> receptor agonist, [βAla<sup>8</sup>]neurokinin A (4–10) (10 µg·kg·kg–1</sup> i.v.) was observed after intravenous administration of YM-44781 and Ym-44778.