A. Choppin

Publications31
h-index14
Citations966
Highly Influential Citations51
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Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
TLDR
In urethane‐anaesthetized rats, the cholinergic component of volume‐induced bladder contractions was inhibited by muscarinic antagonists but had marginal effects on pinacidil‐induced, adenosine 3′:5′‐cyclic monophosphate (cyclic AMP)‐independent, relaxation, consistent with a major contribution of M2 receptors in the generation of volume-induced bladdercontractions.
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Muscarinic receptor ligands and their therapeutic potential.
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Therapeutic opportunities from muscarinic receptor research.
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Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle
TLDR
Overall, these data study suggest that muscarinic M3 receptors are the predominant, if not the exclusive, subtype mediating contractile responses to mus carinic agonists in male mouse urinary bladder smooth muscle.
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Pharmacological characterization of muscarinic receptors in rabbit isolated iris sphincter muscle and urinary bladder smooth muscle
TLDR
The data from this study suggest that the muscarinic receptors mediating contraction of the rabbit iris sphincter muscle and urinary bladder smooth muscle are similar and equate most closely with the pharmacologically‐defined mus carinic M3 receptor.
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5-Hydroxytryptamine1D-like receptors mediate contraction of partially depolarized rabbit renal arteries.
This study characterizes the 5-hydroxytryptamine (5-HT) receptors involved in the contraction of rabbit renal arteries which had been previously precontracted submaximally by partial depolarization.…
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Presence of vasoconstrictor 5HT1‐like receptors revealed by precontraction of rabbit isolated mesenteric artery
TLDR
This study demonstrates a particularly striking example of vasoconstrictor synergy involving 5‐HT1‐like receptors, based on the agonist potency order and the antagonist studies performed, and shows that the receptor subtype responsible has the characteristics of a 5‐hydroxytryptamine‐like (probably 5‐ HT1D) receptor.
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Pre-contraction with histamine and U46619 unmasks a 5-HT1-like receptor in rabbit renal artery.
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Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains
  • A. Choppin
  • Biology
    British journal of pharmacology
  • 1 October 2002
TLDR
It is suggested that muscarinic M3 receptors are the predominant, if not the exclusive, subtype mediating contractile responses to muscaric agonists in female mouse urinary bladder smooth muscle, with strain differences.
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Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle
TLDR
It is suggested that the dog urinary bladder contracts in response to M3 muscarinic receptor activation, and the brown‐eyed dog ciliary muscle is more complex and may include involvement of at least two receptors, possibly the M5 and M3 receptor, whereas blue‐eyedDog ciliary Muscle may involve a single population of M5 mus carinic receptors.
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