Effect of neurokinins on canine prostate cell physiology

  title={Effect of neurokinins on canine prostate cell physiology},
  author={Paul D. Walden and Dorene Marinese and Dinesh Kumar Srinivasan and Elda Tzoumaka and Harley T. Syyong and Anthony P.D.W. Ford and Anindya Bhattacharya},
  journal={The Prostate},
Sensory peptide neurotransmitters have been implicated as significant regulators of prostate growth. This study was designed to evaluate the role of neurokinins in proliferation, differentiation, and contraction of canine prostate cells in culture. 
Effect of Onabotulinum Toxin A on Substance P and Receptor Neurokinin 1 in the Rat Ventral Prostate.
BoNTA treatment decreases substance P in the rat VP and its receptor neurokinin 1 localization and quantification were performed by counting the number of stained neurons and nerve bundles, by semi-quantitative immunohistochemical analysis and by western analysis.
Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction
It was revealed from documented reports that the vast majority of neuropeptides present in the autonomic nerve supply to the male genital tract probably coexist with other peptides or with various neurotransmitters (tyrosine hydroxylase, dopamine beta hydroxyase, and 5-hydroxytryptamine).
Age-related changes in the innervation of the prostate gland
The influence of the sympathetic nervous system on benign prostatic hyperplasia is well documented and the possibility of a link between changes in autonomic innervation and prostate cancer progression is considered.


Mechanistic investigation of the adrenergic induction of ventral prostate hyperplasia in mice
The norepinephrine (NE) analog phenylephrine has previously been shown to induce atypical prostate hyperplasia in rats, and this study provides further insight into the mechanism of Phenylephrine‐induced prostate growth.
Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation
This study deals with the prostatic effect of subchronic sympathomimetic stimulation of adrenergic agonists in patients with benign prostatic hyperplasia.
Neuroendocrine cells and nerves in the prostate of the guinea pig: Effects of peripheral denervation and castration
The effects of peripheral denervation and castration on NE cells and nerves in the guinea pig prostate are described.
Species Differences In The Actions Of Sensory Neuropeptides On Contractility Of The Smooth Muscle Of The Rat And Guinea‐Pig Prostate
1. The present review describes the actions of sensory neuropeptides on the contractility of the rat and guinea‐pig prostate gland and discusses the differences in sensitivity of the smooth muscle of
Peripheral actions of tachykinins
Preclinical evidence obtained through the use of selective tachykinin receptor antagonists indicates that endogenous tachyKinins are involved in augmented smooth muscle contraction, vasodilatation, chemotaxis and activation of immune cells, mucus secretion, water absorption/secretion.
Pharmacological characterization of canine bradykinin receptors in prostatic culture and in isolated prostate
It is concluded that canine prostates express functional B2 receptors, with no apparent B1 receptor subtypes.
Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.
The contractile effect of two highly potent, selective and peptidase-resistant neurokinin (NK) 1 and NK2 receptor agonists, namely delta-Aminovaleryl and N-MeLeu10, was investigated on smooth muscle strips dissected from specimens of human detrusor, prostatic urethra and prostate, considering possible therapeutic implications in the treatment of urinary bladder disorders.