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What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine.
- T. Ogihara, Masatsugu Kamiya, Y. Isomura
- Biology, MedicineDrug metabolism and pharmacokinetics
- 2006
The influence of P-glycoprotein (P-gp) on intestinal absorption of drugs was investigated by comparison of the uptakes of two P-gp substrates, verapamil and vinblastine, using intestinal segments of…
Antitumor activity of shikonin and its derivatives.
- U. Sankawa, Y. Ebizuka, T. Miyazaki, Y. Isomura, H. Otsuka
- Chemistry, MedicineChemical & pharmaceutical bulletin
- 25 September 1977
Shikonin, a naphthoquinone contained in the root of Lithospermum officinalis var. erythrorhizon MAX. and Macrotomia euchroma (ROYLE) PAULS (Boraginaceae), showed a high antitumor activity against the…
Studies on novel bone resorption inhibitors. II. Synthesis and pharmacological activities of fused aza-heteroarylbisphosphonate derivatives.
- M. Takeuchi, S. Sakamoto, K. Kawamuki, H. Kurihara, H. Nakahara, Y. Isomura
- Chemistry, BiologyChemical & pharmaceutical bulletin
- 15 November 1998
Two new series of fused aza-heteroarylbisphosphonates (5, 8), which are structurally quite different from incadronate (YM175), and related compounds were synthesized and evaluated for antiresorptive…
Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.
- Y. Okamoto, H. Anan, Y. Isomura
- ChemistryChemical & pharmaceutical bulletin
- 15 January 1999
TLDR
Studies on novel bone resorption inhibitors. I. Synthesis and pharmacological activities of aminomethylenebisphosphonate derivatives.
- M. Takeuchi, S. Sakamoto, M. Yoshida, T. Abe, Y. Isomura
- Chemistry, BiologyChemical & pharmaceutical bulletin
- 15 April 1993
TLDR
One-Pot Preparation of 1-Substituted Imidazole-2-thione from Isothiocyanate and Amino Acetal
- Koyo. Matsuda, I. Yanagisawa, Y. Isomura, T. Mase, T. Shibanuma
- Chemistry
- 1 October 1997
Abstract Isothiocyanates were treated with amino acetal and conc. HCl (0.5 eq.) successively in one-pot to afford 1-substituted imidazole-2-thiones in good yields.
Alternative Synthesis of Dibenzo-and Dipyrido-[1,3]Diazepines from Thioamides and o,o′-Diaminobiaryls
- Koyo. Matsuda, I. Yanagisawa, Y. Isomura, T. Mase, T. Shibanuma
- Chemistry
- 1 July 1997
Abstract Thioamides were treated with iodomethane, and then o,o′-diaminobiphenyl or bipyridyl to afford 6-substituted-5H-dibenzo- or dipyrido [1,3]diazepines in good yields.
Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
- K. Tamazawa, H. Arima, M. Terai
- ChemistryJournal of medicinal chemistry
- 1 December 1986
Four enantiomers (3a-d) of the title compound, YM-09730 (3), were synthesized by the reaction of (-)- or (+)-5-(methoxycarbonyl)-2, 6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid…
Studies on aromatase inhibitors. I. Synthesis and biological evaluation of 4-amino-4H-1,2,4-triazole derivatives.
- M. Okada, T. Yoden, T. Fujikura
- Chemistry, BiologyChemical & pharmaceutical bulletin
- 15 October 1996
TLDR
Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE).
- G. Semple, D. Ashworth, Y. Isomura
- Chemistry, BiologyBioorganic & medicinal chemistry letters
- 21 April 1998
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