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Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and… Expand Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour… Expand The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with… Expand The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. The novel bi-aryl urea BAY… Expand One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising… Expand Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and… Expand TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their… Expand The partial pressure of oxygen (pO2) and pH play critical roles in tumor biology and therapy. We report here the first combined… Expand Molecular size is one of the key determinants of transvascular transport of therapeutic agents in tumors. However, there are no… Expand To characterize cell surface molecules involved in control of growth of malignant lymphocytes, monoclonal antibodies were raised… Expand