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The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.
Xotx2, a Xenopus homeobox gene related to orthodenticle, a gene expressed in the developing head of Drosophila, is studied, suggesting a role in the specification of very anterior structures. Expand
Nested expression domains of four homeobox genes in developing rostral brain
The expression domains of the four genes in the developing rostral brain of mouse embryos at a developmental stage, day 10 post coitum, seem to be continuous regions contained within each other in the sequence Emxl < Emx2 < Otxl< Otx2. Expand
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.
The expression patterns of the two genes in diencephalon suggest that they both have a role in establishing the boundary between presumptive dorsal and ventral thalamus and in anterior neuroectoderm, demarcating rostral brain regions even before headfold formation. Expand
Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.
We cloned two homeobox genes, Emx1 and Emx2, related to empty spiracles, a gene expressed in very anterior body regions during early Drosophila embryogenesis, and studied their expression in mouseExpand
The caudal limit of Otx2 expression positions the isthmic organizer
Findings show that the caudal limit of Otx2 expression is sufficient for positioning the isthmic organizer and encoding caUDal midbrain fate within the mid/hindbrain domain. Expand
Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of
Homologies between vertebrate forebrain subdivisions are still uncertain. In particular the identification of homologs of the mammalian neocortex or the dorsal ventricular ridge (DVR) of birds andExpand
Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice
It is found that the normal spectrum of cortical areal identities was encoded in these mutants, but areas with caudal–medial identities were reduced and those with anterior–lateral identities were relatively expanded in the cortex. Expand
Dentate gyrus formation requires Emx2.
It is demonstrated that Emx2 is required for the development of several forebrain structures in mice with specific morphological alterations in allocortical structures of the medial wall of the brain. Expand
Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium.
It is found that Emx2 and Pax6 are necessary for the establishment of their own specific expression profiles and are able to down-regulate each other; and absence of functional EMX2 or PAX6 proteins results in reduction of caudal-medial and rostral-lateral cortical regions, respectively. Expand
The Lack of Emx2 Causes Impairment ofReelin Signaling and Defects of Neuronal Migration in the Developing Cerebral Cortex
The development of radial glia is impaired, neurons making up the cortical plate display abnormal migration patterns, and restricted defects along the rostrocaudal and the mediolateral axes are present in the subplate, suggesting an Emx2-specific role in priming the proper development of this layer. Expand