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De Novo Gene Disruptions in Children on the Autistic Spectrum
Exome sequencing of 343 families, each with a single child on the autism spectrum and at least one unaffected sibling, reveal de novo small indels and point substitutions, which come mostly from theExpand
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Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.
  • P. Andrews
  • Biology, Medicine
  • Developmental biology
  • 1 June 1984
The human embryonal carcinoma cell lines NT2 /D1 and NT2 /B9, clonally derived from Tera-2, differentiate extensively in vitro when exposed to retinoic acid. This differentiation is marked by theExpand
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Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
The International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation andExpand
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Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among theExpand
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Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
We have derived and characterized single cell clones from a xenograft tumor of the teratocarcinoma cell line Tera-2. Isozyme and chromosomal analyses confirmed their common origin. When cultures ofExpand
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Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells
We have observed karyotypic changes involving the gain of chromosome 17q in three independent human embryonic stem (hES) cell lines on five independent occasions. A gain of chromosome 12 was seenExpand
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OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells
OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4Expand
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Adaptation to culture of human embryonic stem cells and oncogenesis in vivo
The application of human embryonic stem cells (HESCs) to provide differentiated cells for regenerative medicine will require the continuous maintenance of the undifferentiated stem cells for longExpand
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Restoration of auditory evoked responses by human ES cell-derived otic progenitors
Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms of deafness,Expand
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Surface antigens of human embryonic stem cells: changes upon differentiation in culture *
We have analysed the surface antigen phenotype of a human embryonic stem (hES) cell line (H7) and the changes that occur upon differentiation induced by retinoic acid, hexamethylene bisacetamide andExpand
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