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XRCC5 wt Allele

Known as: X-ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) wt Allele, Ku80, NFIV 
Human XRCC5 wild-type allele is located within 2q35 and is approximately 99 kb in length. This allele, which encodes X-ray repair cross-complementing… Expand
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
The Ku heterodimer (Ku70 and Ku80 subunits) contributes to genomic integrity through its ability to bind DNA double-strand breaks… Expand
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Highly Cited
2000
Highly Cited
2000
Cancer susceptibility genes have been classified into two groups: gatekeepers and caretakers. Gatekeepers are genes that control… Expand
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Highly Cited
1999
Highly Cited
1999
DNA double-strand breaks formed during the assembly of antigen receptors or after exposure to ionizing radiation are repaired by… Expand
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Highly Cited
1998
Highly Cited
1998
The DNA-end-joining reactions used for repair of double-strand breaks in DNA and for V (D)J recombination, the process by which… Expand
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Highly Cited
1998
Highly Cited
1998
Isotype switching is the DNA recombination mechanism by which antibody genes diversify immunoglobulin effector functions. In… Expand
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Highly Cited
1997
Highly Cited
1997
V(D)J recombination requires both lymphoid-specific and generally expressed enzymatic activities. All three known generally… Expand
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Highly Cited
1996
Highly Cited
1996
Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80, respectively) that binds to DNA ends… Expand
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Highly Cited
1996
Highly Cited
1996
THE DNA-dependent protein kinase (DNA-PK) is a mammalian serine/threonine kinase that is implicated in the repair of DNA double… Expand
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Highly Cited
1996
Highly Cited
1996
Ku is a heterodimeric DNA end binding complex composed of 70 and 86 kDa subunits. Here, we show that Ku86 is essential for normal… Expand
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Highly Cited
1994
Highly Cited
1994
The radiosensitive mutant xrs-6, derived from Chinese hamster ovary cells, is defective in DNA double-strand break repair and in… Expand
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