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XRCC5 wt Allele

Known as: X-ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) wt Allele, Ku80, NFIV 
Human XRCC5 wild-type allele is located within 2q35 and is approximately 99 kb in length. This allele, which encodes X-ray repair cross-complementing… 
National Institutes of Health

Related topics

Related topics

12 relations
2q35Chromosomal translocationDNA RepairHomo sapiens

Broader (1)

XRCC5 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.
Highly Cited
2005
Highly Cited
2005
Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and γ radiation
Ku protein is a heterodimer (Ku70 and Ku86) known to play an important role in V(D)J recombination, apoptosis, telomere fusion… 
Highly Cited
2004
Highly Cited
2004
Role of Human Ku86 in Telomere Length Maintenance and Telomere Capping
The role of Ku86 at telomeres has been extensively studied in various organisms; however, a role for Ku86 at human telomeres was… 
Highly Cited
2003
Highly Cited
2003
Telomerase Dependence of Telomere Lengthening in ku80 Mutant Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.008623.
We have identified a ku80 mutant of Arabidopsis and show that telomerase is needed to generate the longer telomeres observed in… 
Highly Cited
2003
Highly Cited
2003
Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis.
Highly Cited
2001
Highly Cited
2001
Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
DNA-dependent protein kinase (DNA-PK), consisting of a catalytic subunit (DNA-PKcs) and the Ku70 and Ku86 proteins, participates… 
2001
2001
Human Ku70 interacts with heterochromatin protein 1alpha.
Ku is involved in the metabolism of DNA ends, DNA repair, and the maintenance of telomeres. It consists of a heterodimer of 70… 
Highly Cited
2000
Highly Cited
2000
Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage1
Ku is a heterodimer of Ku70 and Ku86 that binds to double-stranded DNA breaks (DSBs), activates the catalytic subunit (DNA-PKcs… 
Highly Cited
1998
Highly Cited
1998
Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man
We examined the timing of apoptosis and the expression of the DNA repair proteins poly(ADP-ribose) polymerase (PARP) and Ku80 in… 
Highly Cited
1996
Highly Cited
1996
Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.
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