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The Hallmarks of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for majorExpand
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Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. MammalianExpand
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Telomeres and human disease: ageing, cancer and beyond
  • M. Blasco
  • Medicine, Biology
  • Nature Reviews Genetics
  • 1 August 2005
Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which canExpand
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Cellular Senescence in Cancer and Aging
Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage.Expand
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The Ink4/Arf locus is a barrier for iPS cell reprogramming
The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remainExpand
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet wereExpand
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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeresExpand
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Essential role of mouse telomerase in highly proliferative organs
We have investigated the role of the enzyme telomerase in highly proliferative organs in successive generations of mice lacking telomerase RNA. Late-generation animals exhibited defectiveExpand
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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides anExpand
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The epigenetic regulation of mammalian telomeres
  • M. Blasco
  • Medicine, Biology
  • Nature Reviews Genetics
  • 1 April 2007
Increasing evidence indicates that chromatin modifications are important regulators of mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin formation in yeast and flies,Expand
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