The Hallmarks of Aging
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
It is reported that telomeric repeats are transcribed by DNA-dependent RNA polymerase II, which, in turn, interacts with the TRF1 shelterin protein, suggesting that TelRNAs may regulate telomerase activity at chromosome ends.
Telomeres and human disease: ageing, cancer and beyond
- M. Blasco
- Biology, MedicineNature reviews genetics
- 1 August 2005
Altered functioning of both telomerase and telomere-interacting proteins is present in some human premature ageing syndromes and in cancer, and recent findings indicate that alterations that affect telomeres at the level of chromatin structure might also have a role in human disease.
Cellular Senescence in Cancer and Aging
The Ink4/Arf locus is a barrier for iPS cell reprogramming
It is concluded that the silencing of Ink4/Arf locus is rate-limiting for reprogramming, and its transient inhibition may significantly improve the generation of iPS cells.
Essential role of mouse telomerase in highly proliferative organs
Findings indicate an essential role for telomerase, and hence telomeres, in the maintenance of genomic integrity and in the long-term viability of high-renewal organ systems.
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Secondary Structure of Vertebrate Telomerase RNA
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Observations indicate that during reprogramming cells increase their intolerance to different types of DNA damage and that p53 is critical in preventing the generation of human and mouse pluripotent cells from suboptimal parental cells.
The epigenetic regulation of mammalian telomeres
- M. Blasco
- BiologyNature reviews genetics
- 1 April 2007
The links between epigenetic status and telomere-length regulation provide important new avenues for understanding processes such as cancer development and ageing, which are characterized by telomeres-length defects.