Human Ku70 interacts with heterochromatin protein 1alpha.

  title={Human Ku70 interacts with heterochromatin protein 1alpha.},
  author={K H Song and Y Jung and David Jung and In-ae Lee},
  journal={The Journal of biological chemistry},
  volume={276 11},
Ku is involved in the metabolism of DNA ends, DNA repair, and the maintenance of telomeres. It consists of a heterodimer of 70- and 80-kDa subunits. Recently we have demonstrated that Ku70 interacted with TRF2, a mammalian telomere-binding protein. Using the same yeast two-hybrid screening system, we now show that Ku70 also interacts with heterochromatin protein 1alpha (HP1alpha), a protein known to be associated with telomeres as well as heterochromatin. HP1 is a suppressor of the position… CONTINUE READING
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