XRCC5 gene

Known as: Ku80, X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 5, Ku ANTIGEN, 80-KD SUBUNIT 
This gene is involved in DNA repair via the nonhomologous end-joining pathway.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
The insertion of precise genetic modifications by genome editing tools such as CRISPR-Cas9 is limited by the relatively low… (More)
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Highly Cited
2009
Highly Cited
2009
As with other organisms with a completed genome sequence, opportunities for performing large-scale studies, such as expression… (More)
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Highly Cited
2008
Highly Cited
2008
ERCC1-XPF endonuclease is required for nucleotide excision repair (NER) of helix-distorting DNA lesions. However, mutations in… (More)
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Highly Cited
2006
Highly Cited
2006
Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies. However… (More)
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Highly Cited
2006
Highly Cited
2006
To increase the frequency of homologous recombination, we inactivated the KU80 homologue in Aspergillus fumigatus (named akuB… (More)
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Highly Cited
2004
Highly Cited
2004
Gene disruption and overexpression play central roles in the analysis of gene function. Homologous recombination is, in principle… (More)
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Highly Cited
2002
Highly Cited
2002
Blimp-1, a transcriptional repressor, drives the terminal differentiation of B cells to plasma cells. Using DNA microarrays, we… (More)
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Highly Cited
1999
Highly Cited
1999
Recent findings intriguingly place DNA double-strand break repair proteins at chromosome ends in yeast, where they help maintain… (More)
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Highly Cited
1998
Highly Cited
1998
Isotype switching is the DNA recombination mechanism by which antibody genes diversify immunoglobulin effector functions. In… (More)
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Highly Cited
1996
Highly Cited
1996
Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80, respectively) that binds to DNA ends… (More)
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