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XRCC5 gene

Known as: Ku80, X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 5, Ku ANTIGEN, 80-KD SUBUNIT 
This gene is involved in DNA repair via the nonhomologous end-joining pathway.
National Institutes of Health

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Related topics

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Chromosomal translocationDNA RepairLupus Erythematosus, SystemicMalignant Neoplasms

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XRCC5 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Enhanced Use of Backup Pathways of NHEJ in G2 in Chinese Hamster Mutant Cells with Defects in the Classical Pathway of NHEJ
Abstract Wu, W., Wang, M., Mussfeldt, T. and Iliakis, G. Enhanced Use of Backup Pathways of NHEJ in G2 in Chinese Hamster Mutant… 
Highly Cited
2007
Highly Cited
2007
The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.
Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two… 
Highly Cited
2004
Highly Cited
2004
Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) Polymerase-1*
Werner's syndrome (WS) is an inherited disease characterized by genomic instability and premature aging. The WS gene encodes a… 
Highly Cited
2003
Highly Cited
2003
Telomerase Dependence of Telomere Lengthening in ku80 Mutant Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.008623.
We have identified a ku80 mutant of Arabidopsis and show that telomerase is needed to generate the longer telomeres observed in… 
Highly Cited
2000
Highly Cited
2000
Lysyl Oxidase Activates the Transcription Activity of Human Collagene III Promoter
Lysyl oxidase is an extracellular enzyme that controls the maturation of collagen and elastin. Lysyl oxidase and collagen III… 
Highly Cited
2000
Highly Cited
2000
Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage1
Ku is a heterodimer of Ku70 and Ku86 that binds to double-stranded DNA breaks (DSBs), activates the catalytic subunit (DNA-PKcs… 
Highly Cited
1998
Highly Cited
1998
Differential etoposide sensitivity of cells deficient in the Ku and DNA-PKcs components of the DNA-dependent protein kinase.
Etoposides block cell division by interfering with the action of topoisomerase II, leaving enzyme-DNA double-strand breaks. We… 
Highly Cited
1996
Highly Cited
1996
Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.
Highly Cited
1995
Highly Cited
1995
DNA strand break rejoining defect in xrs-6 is complemented by transfection with the human Ku80 gene.
The radiosensitive mutant xrs-6, derived from Chinese hamster ovary cell line CHO-K1, has been demonstrated to be defective in… 
Highly Cited
1992
Highly Cited
1992
Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.
Complementation of the repair defect in hamster xrs mutants has been achieved by transfer of human chromosome 2 using the method… 
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