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XRCC5 gene

Known as: Ku80, X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 5, Ku ANTIGEN, 80-KD SUBUNIT 
This gene is involved in DNA repair via the nonhomologous end-joining pathway.
National Institutes of Health

Related topics

Related topics

10 relations
Chromosomal translocationDNA RepairLupus Erythematosus, SystemicMalignant Neoplasms

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XRCC5 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
The ubiquitination cascade has a key role in the assembly of repair and signaling proteins at sites of double-strand DNA breaks… 
Highly Cited
2008
Highly Cited
2008
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.
Artesunate is a semisynthetic derivative from artemisinin, a natural product from the Chinese herb Artemisia annua L. It exerts… 
Highly Cited
2008
Highly Cited
2008
Ku80 removal from DNA through double strand break–induced ubiquitylation
The Ku70/Ku80 heterodimer, or Ku, is the central component of the nonhomologous end joining (NHEJ) pathway of double strand break… 
Highly Cited
2003
Highly Cited
2003
Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.
The role of the familial breast cancer susceptibility genes, BRCA1 and BRCA2, in the homologous recombination pathway for DNA… 
Highly Cited
2003
Highly Cited
2003
Nonhomologous end joining and V(D)J recombination require an additional factor
DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in mammalian cells. It also… 
Highly Cited
2002
Highly Cited
2002
Ku86 is essential in human somatic cells
Ku86 plays a key role in nonhomologous end joining in mammals. Functional inactivation in rodents of either Ku86 or Ku70, which… 
Highly Cited
2000
Highly Cited
2000
Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing*
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging. The gene responsible for the syndrome… 
Highly Cited
1998
Highly Cited
1998
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA… 
Highly Cited
1997
Highly Cited
1997
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.
V(D)J recombination requires both lymphoid-specific and generally expressed enzymatic activities. All three known generally… 
Highly Cited
1996
Highly Cited
1996
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.
Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80, respectively) that binds to DNA ends… 
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