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XRCC2 protein, human

Known as: XRCC2, X-Ray Repair Cross Complementing Protein 2, X-Ray Repair, Complementing Defective, Repair In Chinese Hamster 
DNA repair protein XRCC2 (280 aa, ~32 kDa) is encoded by the human XRCC2 gene. This protein plays a role in DNA double-strand break repair.
National Institutes of Health

Related topics

Related topics

17 relations
Cell NucleusDNA RepairDNA Repair GeneDNA repair protein

Broader (1)

DNA-Binding Proteins

Papers overview

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Highly Cited
2010
Highly Cited
2010
The importance of XRCC2 in RAD51-related DNA damage repair.
Highly Cited
2008
Highly Cited
2008
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
BACKGROUND The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung… 
2005
2005
The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C.
Homologous recombination (HR) is a mechanism for repairing DNA interstrand crosslinks and double-strand breaks. In mammals, HR… 
Highly Cited
2002
Highly Cited
2002
Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin.
The anticancer drug cisplatin reacts with DNA leading to the formation of interstrand and intrastrand cross-links that are the… 
Highly Cited
2002
Highly Cited
2002
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
Genetic studies in rodent and chicken mutant cell lines have suggested that Rad51 paralogs (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C… 
Highly Cited
2002
Highly Cited
2002
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines.
Loss of mismatch repair (MMR) leads to a complex mutator phenotype that appears to drive the development of a subset of colon… 
Highly Cited
2002
Highly Cited
2002
A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.
An acquired genetic instability, resulting from the loss of some types of DNA repair, is an early event in the development of a… 
Highly Cited
2001
Highly Cited
2001
XRCC2 Is a Nuclear RAD51-like Protein Required for Damage-dependent RAD51 Focus Formation without the Need for ATP Binding*
The human XRCC2 gene was recently identified by its ability to complement a hamster cell line, irs1, which is sensitive to DNA… 
Highly Cited
2000
Highly Cited
2000
The RAD51 Family Member, RAD51L3, Is a DNA-stimulated ATPase That Forms a Complex with XRCC2*
The Rad51 protein in eukaryotic cells is a structural and functional homolog of Escherichia coli RecA with a role in DNA repair… 
Highly Cited
2000
Highly Cited
2000
Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants
The radiosensitizing effect of caffeine has been associated with the disruption of multiple DNA damage-responsive cell cycle… 
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