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Werner Syndrome

Known as: syndromes werner's, PROGERIA, OF ADULT, Adult Progeria 
An inherited disorder marked by rapid aging that begins in early adolescence. Patients may be shorter than average, and have health problems such as… 
National Institutes of Health

Related topics

Related topics

33 relations
Autosomal recessive inheritanceCataractChromosomes, Human, Pair 8Diabetes Mellitus

Broader (3)

Hereditary DiseasesPremature aging syndromeSyndrome

Narrower (2)

Lipomatosis, Multiple SymmetricalPeptide growth factors deficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Accelerated epigenetic aging in Werner syndrome
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying… 
Highly Cited
2015
Highly Cited
2015
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater… 
Highly Cited
2002
Highly Cited
2002
Homologous Recombination Resolution Defect in Werner Syndrome
ABSTRACT Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging… 
Highly Cited
2000
Highly Cited
2000
Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest
Individuals affected by the autosomal recessive disorder Werner's syndrome (WS) develop many of the symptoms characteristic of… 
Highly Cited
2000
Highly Cited
2000
Ku complex interacts with and stimulates the Werner protein.
Werner syndrome (WS) is the hallmark premature aging disorder in which affected humans appear older than their chronological age… 
Highly Cited
1999
Highly Cited
1999
Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG) n *
Formation of hairpin and tetrahelical structures by a d(CGG) trinucleotide repeat sequence is thought to cause expansion of this… 
Highly Cited
1999
Highly Cited
1999
The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I*
Werner syndrome (WS) is a recessive disorder characterized by genomic instability and by the premature onset of a number of age… 
Highly Cited
1996
Highly Cited
1996
SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.
The Saccharomyces cerevisiae SGS1 gene is homologous to Escherichia coli RecQ and the human BLM and WRN proteins that are… 
Highly Cited
1992
Highly Cited
1992
Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts.
Highly Cited
1989
Highly Cited
1989
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
Werner syndrome (WS) is a rare autosomal-recessive disorder characterized by the premature appearance of features of normal aging… 
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