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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
It is shown that in skeletal muscle of both rodents and humans, a diet high in fat increases the H(2)O(2)-emitting potential of mitochondria, shifts the cellular redox environment to a more oxidized state, and decreases the redox-buffering capacity in the absence of any change in mitochondrial respiratory function.
mTOR is a key modulator of ageing and age-related disease
Although adverse side effects currently preclude use in otherwise healthy individuals, drugs that target the mTOR pathway could one day become widely used to slow ageing and reduce age-related pathologies in humans.
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
Transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria were generated and the importance of mitochondria as a source of radicals was reinforced.
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis
- S. Someya, Jinze Xu, T. Prolla
- BiologyProceedings of the National Academy of Sciences
- 17 November 2009
Induction of a Bak-dependent mitochondrial apoptosis program in response to oxidative stress is a key mechanism of AHL in C57BL/6J mice.
Mitochondrial point mutations do not limit the natural lifespan of mice
The results strongly indicate that mitochondrial mutations do not limit the lifespan of wild-type mice and that the mutation frequency in mouse mitochondria is more than ten times lower than previously reported.
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
It is shown that clonal diversity measures adapted from ecology and evolution can predict progression to adenocarcinoma in the premalignant condition known as Barrett's esophagus, even when controlling for established genetic risk factors.
Mitochondria and cardiovascular aging.
The evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and biogenesis as well as the crosstalk between mitochondria and cellular signaling in cardiac and vascular aging is reviewed.
mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome
Rapamycin, a drug used clinically as an immunosuppressant and for treatment of certain cancers, delayed the onset and progression of neurological symptoms in a mouse model of Leigh syndrome and significantly extended survival of the animals.
Evolution of neoplastic cell lineages in Barrett oesophagus
The evolutionary relationships of non-random LOH, TP53 and CD KN2A mutations, CDKN2A CpG-island methylation and ploidy during neoplastic progression are determined and indicate that clonal evolution is more complex than predicted by linear models.
Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets
- B. Reid, D. Levine, G. Longton, P. Blount, P. Rabinovitch
- MedicineAmerican Journal of Gastroenterology
- 1 July 2000
A systematic baseline endoscopic biopsy protocol using histology and flow cytometry identifies subsets of patients with Barrett's esophagus at low and high risk for progression to cancer.