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Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively cause cellular damage and lack a… Expand Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The understanding of the risk factors for… Expand The premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by a mutant lamin A (LADelta50). Nuclei in… Expand Mice deficient in the circadian transcription factor BMAL1 (brain and muscle ARNT-like protein) have impaired circadian behavior… Expand Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenance of genomic integrity. Lamin… Expand Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in… Expand The ‘ataxia telangiectasia mutated’ (Atm) gene maintains genomic stability by activating a key cell-cycle checkpoint in response… Expand Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by features reminiscent of marked premature… Expand Although many cellular and organismal changes have been described in aging individuals, a precise, molecular cause of aging has… Expand Werner's syndrome (WS) is an inherited disease with clinical symptoms resembling premature aging. Early susceptibility to a… Expand