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Vincamine

Known as: Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16alpha)-, Vincamine [Chemical/Ingredient] 
A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in… 
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (13)

11-bromovincamineCerebroxineDevincanPervincamine

Broader (3)

Antihypertensive AgentsVasodilator AgentsVinca Alkaloids
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1987
1987
Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents.
Simplifications and modifications of the vincamine molecule led to the discovery of antihypertensive 1,2,3,4,4a,5,6,12b-octahydro… 
1986
1986
Determination of vincamine in plasma by high-performance liquid chromatography with voltammetric detection.
The determination of vincamine in plasma was investigated by high-performance liquid chromatography with voltammetric detection… 
1984
1984
Cerebral antioedematous effect of Teproside and of some vincamine derivatives.
Alkyltin compounds are known to produce in the rat a selective oedema of the CNS, especially of the white matter. Vincamine and… 
1984
1984
Preparation and in vivo studies of a new drug delivery system
Polyhexylcyanoacrylate nanoparticles have been prepared with vincamine as the model drug. These particles had an average size of… 
1982
1982
The metabolic fate of 11-bromo-[15-3H] vincamine in rats, dogs and humans.
During 5d following single oral doses of 3H-11-bromovincamine to rats (10 mg/kg), dogs (10 mg/kg) and humans (0.5 mg/kg), about… 
1979
1979
Comparative study of the clinical effect of vincamine versus papaverine given parenterally in the acute phase of stroke.
The efficacy of the "oxygenator", vincamine was assessed in comparison to a classic vasodilator, papaverine, after parenteral… 
1979
1979
Cerebral metabolic and hemodynamic activities of l-eburnamonine in the anesthetized dog. A comparison with vincamine.
1. The cerebral metabolic and hemodynamic activities of l-eburnamonine (l-E) were investigated in anesthetized dogs and compared… 
1979
1979
[32P-incorporation in adenosine phosphates of the rat brain after oral application of vincamine for 2 weeks (author's transl)].
The 32P-incorporation into the adenosine phosphates AMP, ADP and ATP of the rat brain after an oral administration of a daily… 
1978
1978
Influence of vincamine and piracetam on sleep--waking pattern of the cat.
The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were… 
1978
1978
Determination of vincamine in plasma by selected ion monitoring.
A sensitive and specific method for the determination of vincamine in plasma is described. The molecular ion (m/e 426) and the…