Vinca Alkaloids

Known as: Vinca Alkaloids [Chemical/Ingredient], vinca alkaloid, Vinca Alkaloid Compound 
A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that… (More)
National Institutes of Health

Related topics

Related topics

48 relations
31 ML Vincristine sulfate liposome 0.16 MG/ML InjectionIn BloodVinblastineVinblastine Sulfate
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Narrower (31)

6-hydroxyvinburnineEC 0489EC145LHT 2 - 02
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Broader (4)

AlkaloidsAntineoplastic AgentsTubulin Modulatorscarbazole

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathies: A Comprehensive Literature Review
Neurotoxic anticancer drugs, such as platinum-based anticancer drugs, taxanes, vinca alkaloids, and proteasome/angiogenesis… (More)
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Highly Cited
2008
Highly Cited
2008
Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group.
PURPOSE Several recent trials have shown a significant overall survival (OS) benefit from postoperative cisplatin-based… (More)
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Review
2004
Review
2004
Microtubules as a target for anticancer drugs
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine.
The two second-generation Vinca alkaloids, vinorelbine and vinflunine, affect microtubule dynamics very differently from… (More)
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Highly Cited
2001
Highly Cited
2001
Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.
Vinca alkaloids are used extensively in the treatment of childhood acute lymphoblastic leukemia (ALL) and despite their… (More)
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Highly Cited
1993
Highly Cited
1993
Vinca alkaloids: anti-vascular effects in a murine tumour.
We have investigated the blood flow modifying effects of the vinca alkaloids, vincristine and vinblastine in the murine carcinoma… (More)
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Review
1992
Review
1992
Preclinical and Clinical Pharmacology of Vinca Alkaloids
Vinca alkaloids, including vinblastine, vincristine, vindesine and vinorelbine, are widely used antineoplastic drugs, either as… (More)
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Highly Cited
1991
Highly Cited
1991
Mechanism of inhibition of cell proliferation by Vinca alkaloids.
We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by… (More)
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Highly Cited
1979
Highly Cited
1979
Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.
Starting with an established line of human leukemic lympho blasts (CCRF-CEM), we have developed sublines with varying degrees of… (More)
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Review
1963
Review
1963
THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS.
A phytochemical investigation of the plant Vinca ro@eaLinn. has demonstrated that a number of alkaloidal substances can be… (More)
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