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Vinca Alkaloids

Known as: Vinca Alkaloids [Chemical/Ingredient], vinca alkaloid, Vinca Alkaloid Compound 
A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that… Expand
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (31)

16a'-homo-leurosidine6-hydroxyvinburnineEC 0489LHT 2 - 02
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31 ML Vincristine sulfate liposome 0.16 MG/ML InjectionIn BloodVinblastineVinblastine Sulfate
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Broader (4)

AlkaloidsAntineoplastic AgentsTubulin Modulatorscarbazole

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with… Expand
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Review
2018
Review
2018
PhytoNanotechnology: Enhancing Delivery of Plant Based Anti-cancer Drugs
Natural resources continue to be an invaluable source of new, novel chemical entities of therapeutic utility due to the vast… Expand
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Review
2018
Review
2018
Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead.
Cancer still represents a "nightmare" worldwide, causing annually millions of victims. Several antiproliferative molecules are… Expand
Highly Cited
2008
Highly Cited
2008
Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group.
PURPOSE Several recent trials have shown a significant overall survival (OS) benefit from postoperative cisplatin-based… Expand
Review
2004
Review
2004
Microtubules as a target for anticancer drugs
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted… Expand
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Highly Cited
2001
Highly Cited
2001
Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.
Vinca alkaloids are used extensively in the treatment of childhood acute lymphoblastic leukemia (ALL) and despite their… Expand
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Highly Cited
1991
Highly Cited
1991
Mechanism of inhibition of cell proliferation by Vinca alkaloids.
We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by… Expand
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Review
1990
Review
1990
Taxol: a novel investigational antimicrotubule agent.
Microtubules are among the most strategic subcellular targets of anticancer chemotherapeutics. Despite this fact, new… Expand
Highly Cited
1979
Highly Cited
1979
Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.
Abstract Starting with an established line of human leukemic lymphoblasts (CCRF-CEM), we have developed sublines with varying… Expand
Review
1963
Review
1963
THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS.
Summary A phytochemical investigation of the plant Vinca rosea Linn. has demonstrated that a number of alkaloidal substances can… Expand
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