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Vinca Alkaloids

Known as: Vinca Alkaloids [Chemical/Ingredient], vinca alkaloid, Vinca Alkaloid Compound 
A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with… Expand
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Review
2018
Review
2018
Natural resources continue to be an invaluable source of new, novel chemical entities of therapeutic utility due to the vast… Expand
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Review
2018
Review
2018
Cancer still represents a "nightmare" worldwide, causing annually millions of victims. Several antiproliferative molecules are… Expand
Highly Cited
2008
Highly Cited
2008
PURPOSE Several recent trials have shown a significant overall survival (OS) benefit from postoperative cisplatin-based… Expand
Review
2004
Review
2004
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted… Expand
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Highly Cited
2001
Highly Cited
2001
Vinca alkaloids are used extensively in the treatment of childhood acute lymphoblastic leukemia (ALL) and despite their… Expand
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Highly Cited
1991
Highly Cited
1991
We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by… Expand
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Review
1990
Review
1990
Microtubules are among the most strategic subcellular targets of anticancer chemotherapeutics. Despite this fact, new… Expand
Highly Cited
1979
Highly Cited
1979
Abstract Starting with an established line of human leukemic lymphoblasts (CCRF-CEM), we have developed sublines with varying… Expand
Review
1963
Review
1963
Summary A phytochemical investigation of the plant Vinca rosea Linn. has demonstrated that a number of alkaloidal substances can… Expand
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