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Nanoparticles in cancer therapy and diagnosis.
The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on. Expand
Stimuli-responsive nanocarriers for drug delivery.
Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients). Expand
Nanocarriers’ entry into the cell: relevance to drug delivery
This review will discuss nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes, starting with the phagocytosis pathway. Expand
Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.
- P. Horcajada, T. Chalati, +16 authors R. Gref
- Materials Science, Medicine
- Nature materials
- 1 February 2010
It is shown that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs against cancer and AIDS. Expand
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.
- C. Vauthier, C. Dubernet, E. Fattal, H. Pinto-Alphandary, P. Couvreur
- Materials Science, Medicine
- Advanced drug delivery reviews
- 25 April 2003
An extensive review of the developments and applications of PACAs as nanoparticles for the delivery of drugs is given and considerations concerning the degradation, in vivo distribution, toxicity and cytotoxicity of the nanoparticles are discussed. Expand
Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?
- E. García-García, K. Andrieux, S. Gil, P. Couvreur
- International journal of pharmaceutics
- 25 July 2005
The use of nanotechnologies (liposomes, nanoparticles) is especially discussed in the ultimate part of the review evidencing their potentiality as non-invasive technique in the brain delivery of drugs with the possibility to target specific brain tissue thanks to ligand linked to carrier surface. Expand
Nanotechnology: Intelligent Design to Treat Complex Disease
The purpose of this expert review is to discuss the impact of nanotechnology in the treatment of the major health threats including cancer, infections, metabolic diseases, autoimmune diseases, and… Expand
Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies.
- H. Tapiero, G. Ba, P. Couvreur, K. Tew
- Biology, Medicine
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 July 2002
It is suggested that consumption of a diet enriched in n-3 PUFA and inhibition of COX-2 by NSAIDs may confer cardioprotective effects and provide a significant mechanism for the prevention and treatment of human cancers. Expand
Metal-organic frameworks in biomedicine.
Metal Organic Frameworks in Biomedicine Patricia Horcajada,* Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre*… Expand
Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.
Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et… Expand