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VTCN1 gene

Known as: B7H4, B7X, B7 HOMOLOG 4 
This gene plays a role in the regulation of cell-mediated immunity.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Genes
Immune System ProcessesInterferon Signaling ProcessInterleukin Signaling ProcessNegative Regulation of Lymphocyte Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Host B7-H4 Regulates Antitumor T Cell Responses through Inhibition of Myeloid-Derived Suppressor Cells in a 4T1 Tumor Transplantation Model
B7-H4, a member of the B7 family of T cell immunomodulatory proteins, has been shown to inhibit T cell responses and neutrophil… 
2012
2012
Tissue-Expressed B7x Affects the Immune Response to and Outcome of Lethal Pulmonary Infection
B7x (B7-H4 or B7S1), a member of the B7 family, inhibits in vitro T cell proliferation and cytokine production by binding to an… 
2012
2012
B7-H4 Induces Donor-Specific Tolerance in Mouse Islet Allografts
Negative cosignaling molecules play an important role in regulating T-cell responses to alloantigen stimulation. We recently… 
Highly Cited
2011
Highly Cited
2011
B7-H4 Expression in Human Melanoma: Its Association with Patients' Survival and Antitumor Immune Response
Purpose: Cancers have developed a number of strategies to escape immune responses including the differential expression of… 
2011
2011
The Immunohistochemical Analysis of RCAS1, HLA‐G, and B7H4‐Positive Macrophages in Partial and Complete Hydatidiform Mole in Both Applied Therapeutic Surgery and Surgery Followed by Chemotherapy
Citation Basta P, Galazka K, Mach P, Jozwicki W, Walentowicz M, Wicherek L. The immunohistochemical analysis of RCAS1, HLA‐G, and… 
Highly Cited
2010
Highly Cited
2010
The negative co-signaling molecule b7-h4 is expressed by human bone marrow-derived mesenchymal stem cells and mediates its T-cell modulatory activity.
Though experimental evidence shows that human bone marrow-derived mesenchymal stem cells (hBMSCs) are able to suppress T-cell… 
2010
2010
Expression of B7‐H4 in blood of patients with gastric cancer predicts tumor progression and prognosis
B7‐H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell‐mediated immune response… 
2009
2009
Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival
Background. Allogeneic pancreatic islet transplantation has the potential to cure type 1 diabetes. One of the barriers to islet… 
2009
2009
B7-H4 transfection prolongs beta-cell graft survival.
Highly Cited
2006
Highly Cited
2006
Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice
ABSTRACT Members of the B7 family of cosignaling molecules regulate T-cell proliferation and effector functions by engaging… 
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