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VTCN1 gene

Known as: B7H4, B7X, B7 HOMOLOG 4 
This gene plays a role in the regulation of cell-mediated immunity.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Genes
Immune System ProcessesInterferon Signaling ProcessInterleukin Signaling ProcessNegative Regulation of Lymphocyte Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
The B7x Immune Checkpoint Pathway: From Discovery to Clinical Trial.
Highly Cited
2015
Highly Cited
2015
Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance
ObjectiveImmune escape plays an important role in tumor progression. In the present study, the expression of B7-H1, B7-H4 and… 
Highly Cited
2014
Highly Cited
2014
The coexpression and clinical significance of costimulatory molecules B7-H1, B7-H3, and B7-H4 in human pancreatic cancer
Aim We investigated the expression of the inhibitory costimulatory molecules B7-H1, B7-H3, and B7-H4 in human pancreatic cancer… 
Highly Cited
2011
Highly Cited
2011
B7-H4 Expression in Human Melanoma: Its Association with Patients' Survival and Antitumor Immune Response
Purpose: Cancers have developed a number of strategies to escape immune responses including the differential expression of… 
Highly Cited
2009
Highly Cited
2009
B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.
B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T-cell responses. To explore physiologic roles of… 
Highly Cited
2008
Highly Cited
2008
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome.
Highly Cited
2007
Highly Cited
2007
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
B7-H3 and B7x are recently discovered members of the B7-CD28 family thought to dampen peripheral immune responses via negative… 
Highly Cited
2007
Highly Cited
2007
Evaluation of the novel serum markers B7-H4, Spondin 2, and DcR3 for diagnosis and early detection of ovarian cancer.
Highly Cited
2006
Highly Cited
2006
Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells1
Multiple modes of suppressive mechanisms including IL-10 are thought to be implicated in CD4+CD25+ regulatory T (Treg) cell… 
Highly Cited
2006
Highly Cited
2006
B7-h4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer.
Using cDNA database mining strategies and real-time quantitative reverse transcription-PCR, we identified B7-H4 as a novel gene… 
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