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The convalescent sera option for containing COVID-19.
The efforts in design and synthesis which led to submicromolar covalent inhibitors when the enzymatic activity of the viral protease was used as a screening platform are reported. Expand
Deployment of convalescent plasma for the prevention and treatment of COVID-19.
An overview of convalescent plasma is provided, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. Expand
The damage-response framework of microbial pathogenesis
A new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework, is proposed, which aims to address the impediment to studies of host–microorganism interactions. Expand
Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice.
The experiments demonstrate that MAV-1 has a striking tropism for the CNS that is strain dependent, and this provides an informative in vivo model for the study of adenoviral pathogenesis. Expand
Passive antibody therapy for infectious diseases
Given the need for new antimicrobial therapies and many recent technological advances in the field of immunoglobulin research, there is considerable optimism regarding renewed applications of antibody-based therapy for the prevention and treatment of infectious diseases. Expand
Host-Pathogen Interactions: Basic Concepts of Microbial Commensalism, Colonization, Infection, and Disease
The origin and historical evolution of key concepts used to describe the outcome of host-microbe interactions, namely, infection, commensalism, colonization, persistence, infection and disease, are critically reviewed. Expand
Cryptococcosis in children with AIDS.
A 10-year point prevalence of cryptococcosis among children with AIDS of approximately 1% was estimated on the basis of a subset of the cases. Expand
Host-pathogen interactions: the attributes of virulence.
Virulence is one of a number of possible outcomes of host-microbe interaction. As such, microbial virulence is dependent on host factors, as exemplified by the pathogenicity of avirulent microbes inExpand
Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae.
This work demonstrates the active production of vesicle production by Streptococcus pneumoniae from the plasma membrane, rather than being a product from cell lysis, and shows that pneumococcus produces membrane-derived vesicles particularly enriched in lipoproteins and short-chain fatty acids. Expand
On Virulence
Journal names are important because they often define the scope of the publication. A journal’s name must be sufficiently specific to define the major interest of the publication but not too narrowExpand