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VNP 40101M
Known as:
101M
, VNP-40101M
, VNP40101M
A sulfonyl hydrazine prodrug with antineoplastic activity. VNP40101M alkylates the 06 position of guanine, resulting in DNA crosslinking, strand…
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National Institutes of Health
Topic mentions per year
Topic mentions per year
1991-2018
0
2
4
6
1991
2018
Related topics
Related topics
3 relations
Broader (2)
Alkylating Agents
laromustine
Narrower (1)
Cloretazine
Related mentions per year
Related mentions per year
1946-2018
1940
1960
1980
2000
2020
VNP 40101M
Alkylating Agents
laromustine
Cloretazine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Single-agent laromustine, a novel alkylating agent, has significant activity in older patients with previously untreated poor-risk acute myeloid leukemia.
Gary J. Schiller
,
Susan O'brien
,
+9 authors
Francis J Giles
Journal of clinical oncology : official journal…
2010
PURPOSE An international phase II study of laromustine (VNP40101M), a sulfonylhydrazine alkylating agent, was conducted in…
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2007
2007
Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia.
Francis J Giles
,
David Alan Rizzieri
,
+17 authors
Susan O'brien
Journal of clinical oncology : official journal…
2007
PURPOSE Cloretazine (VNP40101M) is a sulfonylhydrazine alkylating agent with significant antileukemia activity. A multicenter…
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2005
2005
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.
Kevin P. Rice
,
Philip G Penketh
,
Krishnamurthy Shyam
,
Alan C. Sartorelli
Biochemical pharmacology
2005
The antitumor, DNA-alkylating agent 1,3-bis[2-chloroethyl]-2-nitrosourea (BCNU; Carmustine), which generates 2-chloroethyl…
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2005
2005
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Raymond P. Baumann
,
Helen A. Seow
,
Krishnamurthy Shyam
,
Philip G Penketh
,
Alan C. Sartorelli
Oncology research
2005
Cloretazine {1,2-bis(methylsulfonyl)-1-[(2-chloroethyl)-2-(methylamino)carbonyl]hydrazine; VNP40101M; 101M} is a…
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2005
2005
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
Kimiko Ishiguro
,
Krishnamurthy Shyam
,
Philip G Penketh
,
Alan C. Sartorelli
Molecular cancer therapeutics
2005
Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a…
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2004
2004
A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia.
Francis J Giles
,
Deborah Thomas
,
+12 authors
Hagop M Kantarjian
Clinical cancer research : an official journal of…
2004
PURPOSE VNP40101M is a novel sulfonylhydrazine alkylating agent with broad antitumor activity in animal models. As alkylating…
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2003
2003
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity
Raymond P. Baumann
,
K. Shyam
,
Philip G Penketh
,
Joanna S. Remack
,
T. P. Brent
,
Alan C. Sartorelli
Cancer Chemotherapy and Pharmacology
2003
VNP40101M (1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a sulfonylhydrazine prodrug that…
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2002
2002
Ability of the Listeria monocytogenes strain Scott A to cause systemic infection in mice infected by the intragastric route.
Charles J. Czuprynski
,
Nancy G. Faith
,
Howard R Steinberg
Applied and environmental microbiology
2002
Listeriosis is an important food-borne disease that causes high rates of morbidity and mortality. For reasons that are not clear…
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2001
2001
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity.
Robert A. Finch
,
K. Shyam
,
Philip G Penketh
,
Alan C. Sartorelli
Cancer research
2001
Our laboratory has synthesized and evaluated the anticancer activity of a number of sulfonylhydrazine DNA modifying agents. As a…
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1991
1991
Behavior of Listeria monocytogenes in wiener exudates in the presence of Pediococcus acidilactici H or pediocin AcH during storage at 4 or 25 degrees C.
Al‐saleh Yousef
,
John B. Luchansky
,
A J Degnan
,
Margaret Doyle
Applied and environmental microbiology
1991
Exudative fluids were collected from packages of five brands of all-beef wieners and inoculated to contain 10(4) to 10(5) CFU of…
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