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VNP 40101M

Known as: 101M, VNP-40101M, VNP40101M 
A sulfonyl hydrazine prodrug with antineoplastic activity. VNP40101M alkylates the 06 position of guanine, resulting in DNA crosslinking, strand… Expand
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Alkylating Agentslaromustine

Narrower (1)

Cloretazine
hydroxyurea/VNP40101Mtemozolomide/VNP40101M

Papers overview

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2016
2016
Salmonella VNP20009-mediated RNA interference of ABCB5 moderated chemoresistance of melanoma stem cell and suppressed tumor growth more potently
Drug resistance remains an obstacle hindering the success of chemotherapy. Cancer stem cells (CSCs) have been recently found to… Expand
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2016
2016
A Home- and Community-Based Physical Activity Program Can Improve the Cardiorespiratory Fitness and Walking Capacity of Stroke Survivors.
BACKGROUND The cardiorespiratory fitness of stroke survivors is low. Center-based exercise programs that include an aerobic… Expand
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2014
2014
Tumor-specific delivery of histidine-rich glycoprotein suppresses tumor growth and metastasis by anti-angiogenesis and vessel normalization.
Histidine-proline-rich glycoprotein (HPRG) is a plasma protein of vertebrates, which has potent antiangiogenic and tumor vessel… Expand
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2012
2012
Photodynamic activity of viral nanoparticles conjugated with C60.
The development of viral nanoparticles (VNP) displaying multiple copies of the buckyball (C(60)) and their photodynamic activity… Expand
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2010
2010
Earthworm and Soil Carbon Sequestration after Twenty One Years of Continuous No-tillage Corn-Legume Rotation in Indonesia
Soil carbon and earthworm are important components in sustainable tropical agro-ecosystem. Longterm experiment was initially… Expand
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2005
2005
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.
The antitumor, DNA-alkylating agent 1,3-bis[2-chloroethyl]-2-nitrosourea (BCNU; Carmustine), which generates 2-chloroethyl… Expand
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2004
2004
Smart Brick-A Low Cost , Modular Wireless Sensor For Civil Structure Monitoring
We report results on the design and implementation of a low cost wireless multi-sensor system to enable the creation of smart… Expand
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2003
2003
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity
PurposeVNP40101M (1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a sulfonylhydrazine prodrug… Expand
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2003
2003
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by…
PurposeTo investigate the interaction of the electrophilic species generated by the decomposition of the antineoplastic prodrug 1… Expand
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2001
2001
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity.
Our laboratory has synthesized and evaluated the anticancer activity of a number of sulfonylhydrazine DNA modifying agents. As a… Expand
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