FAQ

VNP 40101M

Known as: 101M, VNP-40101M, VNP40101M 
A sulfonyl hydrazine prodrug with antineoplastic activity. VNP40101M alkylates the 06 position of guanine, resulting in DNA crosslinking, strand… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2018
024619912018

Related topics

Related topics

3 relations

Broader (2)

Alkylating Agentslaromustine

Narrower (1)

Cloretazine

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
VNP 40101M
Alkylating Agents
laromustine
Cloretazine

Papers overview

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2010
2010
Single-agent laromustine, a novel alkylating agent, has significant activity in older patients with previously untreated poor-risk acute myeloid leukemia.
PURPOSE An international phase II study of laromustine (VNP40101M), a sulfonylhydrazine alkylating agent, was conducted in… (More)
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2007
2007
Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia.
PURPOSE Cloretazine (VNP40101M) is a sulfonylhydrazine alkylating agent with significant antileukemia activity. A multicenter… (More)
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2005
2005
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.
The antitumor, DNA-alkylating agent 1,3-bis[2-chloroethyl]-2-nitrosourea (BCNU; Carmustine), which generates 2-chloroethyl… (More)
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2005
2005
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Cloretazine {1,2-bis(methylsulfonyl)-1-[(2-chloroethyl)-2-(methylamino)carbonyl]hydrazine; VNP40101M; 101M} is a… (More)
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2005
2005
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a… (More)
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2004
2004
A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia.
PURPOSE VNP40101M is a novel sulfonylhydrazine alkylating agent with broad antitumor activity in animal models. As alkylating… (More)
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2003
2003
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity
VNP40101M (1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a sulfonylhydrazine prodrug that… (More)
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2002
2002
Ability of the Listeria monocytogenes strain Scott A to cause systemic infection in mice infected by the intragastric route.
Listeriosis is an important food-borne disease that causes high rates of morbidity and mortality. For reasons that are not clear… (More)
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2001
2001
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity.
Our laboratory has synthesized and evaluated the anticancer activity of a number of sulfonylhydrazine DNA modifying agents. As a… (More)
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1991
1991
Behavior of Listeria monocytogenes in wiener exudates in the presence of Pediococcus acidilactici H or pediocin AcH during storage at 4 or 25 degrees C.
Exudative fluids were collected from packages of five brands of all-beef wieners and inoculated to contain 10(4) to 10(5) CFU of… (More)
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