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temozolomide/VNP40101M

Known as: TMZ/VNP-40101M 
National Institutes of Health

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2 relations
VNP 40101Mtemozolomide

Papers overview

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2011
2011
Characterization of short-lived electrophilic metabolites of the anticancer agent laromustine (VNP40101M).
Laromustine (VNP40101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino) carbonylhydrazine) is a novel sulfonylhydrazine… 
2009
2009
Effect of cloretazine (VNP40101M) on acute myeloid leukaemia blast cells in vitro as a single agent and combined with cytarabine and daunorubicin.
2007
2007
Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice.
VNP40101M, or 1,2-bis(methylsulfonyl)-1-(2-choloroethyl)-2-(methylamino)carbonylhydrazine (Cloretazine), is a bifunctional… 
2007
2007
Determination of Cloretazine (VNP40101M) and its active metabolite (VNP4090CE) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS).
2005
2005
A phase I and pharmacokinetic study of VNP40101M, a new alkylating agent, in patients with advanced or metastatic cancer
SummaryPurpose: VNP40101M is a new alkylating agent that demonstrated broad anti-tumor activity in murine tumor models. A phase I… 
2005
2005
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine
Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a… 
2004
2004
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by…
PurposeTo investigate the interaction of the electrophilic species generated by the decomposition of the antineoplastic prodrug 1… 
Highly Cited
2004
Highly Cited
2004
A Phase I and Pharmacokinetic Study of VNP40101M, a Novel Sulfonylhydrazine Alkylating Agent, in Patients with Refractory Leukemia
Purpose: VNP40101M is a novel sulfonylhydrazine alkylating agent with broad antitumor activity in animal models. As alkylating… 
2002
2002
Toxicological Evaluation of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine (VNP40101M), a Novel Alkylating Agent with Potential Antitumor Activity, with Intravenous…
These studies investigated the toxicological effects of 1,2-bis (methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl… 
2001
2001
Pharmaceutical development and manufacturing of a parenteral formulation of a novel antitumor agent, VNP40101M
The objective of this study was to develop and manufacture a stable parenteral formulation for Phase I clinical trials of… 
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