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temozolomide

Known as: Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, 3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide, TMZ 
A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Glioblastoma is known to be one of the most lethal and untreatable human tumors. Surgery and radiotherapy in combination with… Expand
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Review
2018
Review
2018
ABSTRACT Despite advances in neurosurgical techniques and radio‐/chemotherapy, the treatment of brain tumors remains a challenge… Expand
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Review
2018
Review
2018
BACKGROUND Pituitary tumours are common and easily treated by surgery or medical treatment in most cases. However, a small subset… Expand
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Review
2018
Review
2018
OBJECTIVE To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and… Expand
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Review
2017
Review
2017
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the… Expand
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Review
2017
Review
2017
The receptor for epidermal growth factor (EGFR) is a prime target for cancer therapy across a broad variety of tumor types. As it… Expand
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Review
2017
Review
2017
Glioblastoma (GBM) is a severe malignant brain cancer with poor overall survival. Conventional intervention remains dismal to… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… Expand
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