temozolomide

Known as: Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, 3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide, TMZ 
A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
020040060019762017

Papers overview

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Review
2016
Review
2016
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Standard therapy for newly diagnosed glioblastoma is radiotherapy plus temozolomide. In this phase 3 study, we… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND In 2004, a randomised phase III trial by the European Organisation for Research and Treatment of Cancer (EORTC) and… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… (More)
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Highly Cited
2004
Highly Cited
2004
AbstractAutophagy is originally named as a process of protein recycling. It begins with sequestering cytoplasmic organelles in a… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE In the setting of a prospective clinical trial, we determined the predictive value of the methylation status of the O-6… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE To compare, in 305 patients with advanced metastatic melanoma, temozolomide and dacarbazine (DTIC) in terms of overall… (More)
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Highly Cited
2000
Highly Cited
2000
A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent… (More)
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