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Cloretazine

 

Topic mentions per year

Topic mentions per year

2005-2015
02420052015

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2 relations

Broader (2)

VNP 40101Mlaromustine

Related mentions per year

Related mentions per year

1991-2018
1990200020102020
Cloretazine
VNP 40101M
laromustine

Papers overview

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2009
2009
Inhibition of human DNA polymerase beta activity by the anticancer prodrug Cloretazine.
The antineoplastic prodrug Cloretazine exerts its cytotoxicity via a synergism between 2-chloroethylating and carbamoylating… (More)
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2008
2008
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
Cloretazine [1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine; VNP40101M; 101M] is a relatively new… (More)
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2007
2007
Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia.
PURPOSE Cloretazine (VNP40101M) is a sulfonylhydrazine alkylating agent with significant antileukemia activity. A multicenter… (More)
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2007
2007
Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme.
Cloretazine (VNP40101M) is a newly synthesized alkylating agent belonging to a novel class of alkylating agents called 1,2-bis… (More)
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2007
2007
Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice.
VNP40101M, or 1,2-bis(methylsulfonyl)-1-(2-choloroethyl)-2-(methylamino)carbonylhydrazine (Cloretazine), is a bifunctional… (More)
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2006
2006
Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine.
Cloretazine is an antitumor sulfonylhydrazine prodrug that generates both chloroethylating and carbamoylating species. The… (More)
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2005
2005
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.
The antitumor, DNA-alkylating agent 1,3-bis[2-chloroethyl]-2-nitrosourea (BCNU; Carmustine), which generates 2-chloroethyl… (More)
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2005
2005
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a… (More)
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2005
2005
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Cloretazine {1,2-bis(methylsulfonyl)-1-[(2-chloroethyl)-2-(methylamino)carbonyl]hydrazine; VNP40101M; 101M} is a… (More)
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2005
2005
Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia.
PURPOSE Cloretazine (VNP40101M) is a novel sulfonylhydrazine alkylating agent with significant antileukemia activity. A phase I… (More)
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