Ursodiol

Known as: Acid, Ursodeoxycholic, 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid, (3?,5?,7?)-3,7-dihydroxycholan-24-oic acid 
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese… (More)
National Institutes of Health

Related topics

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Narrower (25)

23-methylursodeoxycholic acid24-norursodeoxycholic acid3,6-dihydroxy-6-methylcholanoic acid6-fluoro-ursodeoxycholic acid
(More)
Bile Acids and SaltsBiliary cirrhosisCholelithiasisDrug Allergy
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Broader (2)

Cholagogues and CholereticsUrsodeoxycholate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
The ascending pathophysiology of cholestatic liver disease.
In this review we develop the argument that cholestatic liver diseases, particularly primary biliary cholangitis and primary… (More)
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Highly Cited
2006
Highly Cited
2006
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide… (More)
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Highly Cited
2006
Highly Cited
2006
Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid.
BACKGROUND & AIMS Because the efficacy of UDCA on long-term outcome of primary biliary cirrhosis (PBC) has not been completely… (More)
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Highly Cited
2001
Highly Cited
2001
Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.
Patients with ulcerative colitis have an increased risk for colorectal neoplasia; this risk approaches 0.5% to 1% per year of… (More)
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Highly Cited
1998
Highly Cited
1998
Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy.
The association of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) is thought to be rare, and its optimal… (More)
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Highly Cited
1997
Highly Cited
1997
Ursodiol for primary sclerosing cholangitis. Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group.
BACKGROUND There is no satisfactory medical therapy for patients with primary sclerosing cholangitis. Ursodiol (ursodeoxycholic… (More)
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Highly Cited
1995
Highly Cited
1995
A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss.
BACKGROUND Previous studies have documented a high incidence of gallstone formation following gastric-bypass (GBP)-induced rapid… (More)
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Highly Cited
1994
Highly Cited
1994
Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group.
BACKGROUND Ursodiol (ursodeoxycholic acid) therapy leads to major improvements in patients with primary biliary cirrhosis. The… (More)
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Highly Cited
1991
Highly Cited
1991
A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group.
BACKGROUND In primary biliary cirrhosis the hepatic lesions may result, at least in part, from the intracellular accumulation of… (More)
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Review
1991
Review
1991
[Primary biliary cirrhosis].
Primary biliary cirrhosis was described in detail by Popper et al. in 1965. Segmentary necrosis of the interlobular bile ducts… (More)
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