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Ursodiol

Known as: Acid, Ursodeoxycholic, 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid, (3?,5?,7?)-3,7-dihydroxycholan-24-oic acid 
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese… 
National Institutes of Health

Related topics

Related topics

42 relations

Narrower (25)

23-methylursodeoxycholic acid24-norursodeoxycholic acid3,6-dihydroxy-6-methylcholanoic acid6-fluoro-ursodeoxycholic acid
Bile Acids and SaltsBiliary cirrhosisCholelithiasisDrug Allergy

Broader (2)

Cholagogues and CholereticsUrsodeoxycholate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity
Caspases are key mediators in liver inflammation and apoptosis. In the present study we provide evidence that a nitric oxide (NO… 
Review
2000
Review
2000
Drug-induced liver disease.
This year's review has been divided into five sections: The first describes the natural history of drug-induced liver disease… 
Review
1999
Review
1999
Parenteral Nutrition-Associated Cholestasis in Preterm Neonates: Evaluation of Ursodeoxycholic Acid Treatment
BACKGROUND/OBJECTIVE Parenteral nutrition is an integral part of the care of premature infants. Cholestatic liver disease is a… 
Highly Cited
1999
Highly Cited
1999
Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine‐conjugated species in patients with primary biliary cirrhosis
The clinical effectiveness of ursodeoxycholate in the treatment of liver disease may be limited by its poor absorption and… 
Highly Cited
1997
Highly Cited
1997
Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid.
BACKGROUND & AIMS The ileal sodium-dependent bile acid transporter reclaims bile acids from the intestinal lumen to preserve… 
Highly Cited
1994
Highly Cited
1994
Autoimmune cholangiopathy: the result of consecutive primary biliary cirrhosis and autoimmune hepatitis?
Review
1994
Review
1994
Strategy and planning for chemopreventive drug development: Clinical development plans
At the National Cancer Institute, Division of Cancer Prevention and Control, the Chemoprevention Branch and Agent Development… 
Highly Cited
1984
Highly Cited
1984
Effect of Ursodeoxycholic Acid on Biliary Bile Acid and Bile Lipid Composition in Gallstone Patients
In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250, 500, 750, 1,000, and 1… 
Highly Cited
1982
Highly Cited
1982
Bioluminescence measurement of primary bile acids using immobilized 7 alpha-hydroxysteroid dehydrogenase: application to serum bile acids.
A simple, rapid, and sensitive bioluminescence method for measuring primary bile acids has been developed and validated. The… 
Highly Cited
1981
Highly Cited
1981
Nature of bile acid maximum secretory rate in the rat.
We studied the determinants of maximum bile acid secretory rate (SRm) in the rat. The choledochocaval fistula rat model… 
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