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Ursodiol

Known as: Acid, Ursodeoxycholic, 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid, (3?,5?,7?)-3,7-dihydroxycholan-24-oic acid 
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese… 
National Institutes of Health

Related topics

Related topics

42 relations

Narrower (25)

23-methylursodeoxycholic acid24-norursodeoxycholic acid3,6-dihydroxy-6-methylcholanoic acid6-fluoro-ursodeoxycholic acid
Bile Acids and SaltsBiliary cirrhosisCholelithiasisDrug Allergy

Broader (2)

Cholagogues and CholereticsUrsodeoxycholate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
The role of p53 in apoptosis.
The dynamic and multiple functions of p53, together with its involvement in the most common non-infectious diseases, underscore… 
Highly Cited
2005
Highly Cited
2005
The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis.
BACKGROUND AND AIMS We used a multistate modeling approach to assess the effect of ursodeoxycholic acid (UDCA) therapy on the… 
Highly Cited
2001
Highly Cited
2001
Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis
Patients with ulcerative colitis have an increased risk for colorectal neoplasia; this risk approaches 0.5% to 1% per year of… 
Highly Cited
1998
Highly Cited
1998
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.
The hydrophilic bile salt ursodeoxycholic acid (UDCA) protects against the membrane-damaging effects associated with hydrophobic… 
Highly Cited
1998
Highly Cited
1998
Ursodeoxycholic Acid May Inhibit Deoxycholic Acid-Induced Apoptosis by Modulating Mitochondrial Transmembrane Potential and Reactive Oxygen Species Production
BackgroundThe hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat… 
Review
1998
Review
1998
Liver complications of pediatric parenteral nutrition--epidemiology.
Highly Cited
1995
Highly Cited
1995
Effects of Naloxone Infusions in Patients with the Pruritus of Cholestasis: A Double-Blind, Randomized, Controlled Trial
Pruritus is a distressing and frequent complication of cholestasis [1] that is often difficult to manage. It can lead to severe… 
Highly Cited
1994
Highly Cited
1994
The canadian multicenter double‐blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
Ursodeoxycholic acid, a dihydroxyl bile acid normally present in human beings in minimal amounts, becomes incorporated into the… 
Highly Cited
1989
Highly Cited
1989
Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind trial.
Review
1978
Review
1978
Isotope-ratio-monitoring gas chromatography-mass spectrometry
RECEIVED for review February 21, 1978. Accepted June 19, 1978. NMR spectra since two distinct peaks (6 -3.38, 3.78 ppm) caused by… 
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