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Ursodiol
Known as:
Acid, Ursodeoxycholic
, 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid
, (3?,5?,7?)-3,7-dihydroxycholan-24-oic acid
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A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese…
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National Institutes of Health
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Related topics
Related topics
42 relations
Narrower (25)
23-methylursodeoxycholic acid
24-norursodeoxycholic acid
3,6-dihydroxy-6-methylcholanoic acid
6-fluoro-ursodeoxycholic acid
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Bile Acids and Salts
Biliary cirrhosis
Cholelithiasis
Drug Allergy
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Broader (2)
Cholagogues and Choleretics
Ursodeoxycholate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis.
G. Hirschfield
,
U. Beuers
,
+4 authors
C. Schramm
Journal of Hepatology
2017
Corpus ID: 4636965
Highly Cited
2006
Highly Cited
2006
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
Umut Özcan
,
E. Yilmaz
,
+5 authors
G. Hotamışlıgil
Science
2006
Corpus ID: 44000760
Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide…
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Review
2004
Review
2004
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
K. Lindor
,
K. Kowdley
,
+6 authors
P. Colin
Hepatology
2004
Corpus ID: 31802124
No effective medical therapy is available for all patients with nonalcoholic steatohepatitis (NASH). Ursodeoxycholic acid (UDCA…
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Review
2002
Review
2002
Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
G. Paumgartner
,
U. Beuers
Hepatology
2002
Corpus ID: 28282761
Ursodeoxycholic acid (UCDA) is increasingly used for the treatment of cholestatic liver diseases. Experimental evidence suggests…
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Highly Cited
2001
Highly Cited
2001
Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis
B. Tung
,
M. Emond
,
+4 authors
T. Brentnall
Annals of Internal Medicine
2001
Corpus ID: 33953534
Patients with ulcerative colitis have an increased risk for colorectal neoplasia; this risk approaches 0.5% to 1% per year of…
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Review
2000
Review
2000
[Primary sclerosing cholangitis].
A. Stiehl
,
C. Benz
,
P. Sauer
Der Internist
2000
Corpus ID: 467483
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by fibrosing inflammation and…
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Review
1999
Review
1999
The continuing importance of bile acids in liver and intestinal disease.
A. Hofmann
Archives of Internal Medicine
1999
Corpus ID: 21211064
Bile acids, the water-soluble, amphipathic end products of cholesterol metabolism, are involved in liver, biliary, and intestinal…
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Highly Cited
1997
Highly Cited
1997
Ursodiol for Primary Sclerosing Cholangitis
K. Lindor
1997
Corpus ID: 75623582
Background There is no satisfactory medical therapy for patients with primary sclerosing cholangitis. Ursodiol (ursodeoxycholic…
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Highly Cited
1994
Highly Cited
1994
Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group.
R. Poupon
,
R. Poupon
,
B. Balkau
New England Journal of Medicine
1994
Corpus ID: 39940440
BACKGROUND Ursodiol (ursodeoxycholic acid) therapy leads to major improvements in patients with primary biliary cirrhosis. The…
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Highly Cited
1991
Highly Cited
1991
A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group.
R. Poupon
,
B. Balkau
,
E. Eschwège
,
Raoul Poupon
New England Journal of Medicine
1991
Corpus ID: 46141099
BACKGROUND In primary biliary cirrhosis the hepatic lesions may result, at least in part, from the intracellular accumulation of…
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