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- Publications
- Influence
Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation
- R. Zanardo, V. Brancaleone, E. Distrutti, S. Fiorucci, G. Cirino, J. Wallace
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 October 2006
Hydrogen sulfide (H2S) is increasingly recognized as an important signaling molecule in the cardiovascular and nervous systems. Recently, H2S donors were reported to induce neutrophil apoptosis and… Expand
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
- S. Fiorucci, E. Antonelli, +9 authors J. Wallace
- Chemistry, Medicine
- Gastroenterology
- 1 October 2005
BACKGROUND & AIMS
Hydrogen sulfide (H(2)S), an endogenous gaseous mediator that causes vasodilation, is generated in mammalian tissues by cystathionine beta-synthase (CBS) and… Expand
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1
- P. Vavassori, A. Mencarelli, B. Renga, E. Distrutti, S. Fiorucci
- Biology, Medicine
- The Journal of Immunology
- 15 November 2009
The farnesoid X receptor (FXR) is a bile acid-regulated nuclear receptor expressed in enterohepatic tissues. In this study we investigated whether FXR is expressed by cells of innate immunity and… Expand
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.
- S. Fiorucci, E. Antonelli, +6 authors A. Morelli
- Biology, Medicine
- Gastroenterology
- 1 November 2004
BACKGROUND AND AIMS
The farnesoid X receptor (FXR) is an endogenous sensor for bile acids and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene expression. The aim of this… Expand
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies.
- E. Distrutti, L. Monaldi, P. Ricci, S. Fiorucci
- Medicine
- World journal of gastroenterology
- 21 February 2016
In the last decade the impressive expansion of our knowledge of the vast microbial community that resides in the human intestine, the gut microbiota, has provided support to the concept that a… Expand
The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver.
- S. Fiorucci, E. Distrutti, G. Cirino, J. Wallace
- Chemistry, Medicine
- Gastroenterology
- 1 July 2006
Hydrogen sulfide, like nitric oxide, was best known as a toxic pollutant before becoming recognized as a key regulator of several physiologic processes. In recent years, evidence has accumulated to… Expand
Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating KATP Channels
- E. Distrutti, L. Sediari, +8 authors S. Fiorucci
- Medicine
- Journal of Pharmacology and Experimental…
- 1 January 2006
Hydrogen sulfide (H2S) functions as a neuromodulator, but whether it modulates visceral perception and pain is unknown. Cystathionineβ -synthase (CBS) and cystathionine-γ-lyase (CSE) mediate… Expand
Galectin‐1 exerts immunomodulatory and protective effects on concanavalin a–induced hepatitis in mice
- L. Santucci, S. Fiorucci, F. Cammilleri, G. Servillo, B. Federici, A. Morelli
- Biology, Medicine
- Hepatology
- 1 February 2000
Galectin‐1, an endogenous lectin with immunomodulatory activities, induces selective, Fas‐independent apoptosis of activated T cells. The aim of the present study was to evaluate the effect… Expand
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
- S. Cipriani, A. Mencarelli, +6 authors S. Fiorucci
- Biology, Medicine
- PloS one
- 27 October 2011
Background GP-BAR1, a member G protein coupled receptor superfamily, is a cell surface bile acid-activated receptor highly expressed in the ileum and colon. In monocytes, ligation of GP-BAR1 by… Expand
Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis
- S. Fiorucci, G. Rizzo, +6 authors R. Pellicciari
- Biology, Medicine
- Journal of Pharmacology and Experimental…
- 1 October 2005
The nuclear receptors farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)γ exert counter-regulatory effects on hepatic stellate cells (HSCs) and protect against liver… Expand