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Urocanate Hydratase

Known as: Urocaninase, Hydratase, Urocanate, 4,5-Dihydro-4-oxo-5-imidazolepropanoate hydro-lyase 
An enzyme that catalyzes the conversion of 4,5-dihydro-4-oxo-5-imidazolepropanoate to urocanate and water. EC 4.2.1.49.
National Institutes of Health

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In BloodProcess of secretionUROC1 geneantagonists & inhibitors

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Urocanase deficiency

Papers overview

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1993
1993
Cloning, expression and mutational analysis of the urocanase gene (hutU) from Pseudomonas putida.
The histidine-utilizing hutU gene was isolated from a lambda-EMBL3 phage of a genomic library from Pseudomonas putida nicII and… 
1990
1990
Mechanism of action of urocanase. Specific 13C-labelling of the prosthetic NAD+ and revision of the structure of its adduct with imidazolylpropionate.
1. [4-13C]Nicotinate was synthesised and used to support the growth of a nicotinate auxotrophic mutant of Pseudomonas putida. 13C… 
1983
1983
Effect of methionine on in vivo histidine metabolism in rats.
Experiments were conducted to examine the effects of methionine supplementation on histidine metabolism in rats. All animals were… 
1982
1982
A covalent nicotinamide adenine dinucleotide intermediate in the urocanase reaction.
1981
1981
Mechanism of urocanase as studied by deuterium isotope effects and labeling patterns.
Nicotinamide adenine dinucleotide (NAD) dependent urocanase (4'-imidazolone-5'-propionate hydro-lyase, EC 4.2.1.49) from… 
1973
1973
The degradation of L-histidine, imidazolyl-L-lactate and imidazolylpropionate by Pseudomonas testosteroni.
1. Imidazol-5-ylpropionate and imidazol-5-yl-lactate are degraded by Pseudomonas testosteroni via inducible pathways. 2. Growth… 
1973
1973
The control of the enzymes degrading histidine and related imidazolyl derivates in Pseudomonas testosteroni.
1. The induction of the enzymes for the degradation of l-histidine, imidazolylpropionate and imidazolyl-l-lactate in Pseudomonas… 
1973
1973
Folate deficiency and formiminoglutamic acid excretion during chronic diethylnitrosamine administration to rats.
Summary Elevated levels of the histidine catabolite formiminoglutamic acid were excreted into the urine of rats that were given… 
1971
1971
Studies on the mechanism and stereospecificity of the urocanase reaction.
1 Nuclear-magnetic-resonance spectroscopy was used to follow the course of the urocanase reaction. It was shown that 3-(4… 
1965
1965
Histidine metabolism in experimental protein malnutrition in rats.
1. The activities of the enzymes histidase, urocanase and histidine-pyruvate transaminase were studied in rats under conditions… 
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