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UIMC1 wt Allele

Known as: RXRIP110, Receptor-Associated Protein, 80-kD Gene, Ubiquitin Interaction Motif Containing 1 wt Allele 
Human UIMC1 wild-type allele is located in the vicinity of 5q35.2 and is approximately 118 kb in length. This allele, which encodes BRCA1-A complex… 
National Institutes of Health

Related topics

Related topics

5 relations
5q35.2Cell Cycle CheckpointsDNA RepairDouble Strand Break Repair

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
RAP80 expression in breast cancer and its relationship with apoptosis in breast cancer cells
Background RAP80 is a member of BRCA1-A complex, which plays an important role in regulating the cell cycle checkpoint and DNA… 
2018
2018
Association between EGFR mutation and expression of BRCA1 and RAP80 in non-small cell lung cancer
Association between the epithelial growth factor receptor (EGFR) mutation and the expression of breast cancer 1 (BRCA1) and… 
2016
2016
DNA repair pathways to regulate response to chemoradiotherapy in patients with locally advanced head and neck cancer
Platinum-based chemoradiotherapy (CRT) is a preferred standard of care for locally advanced head and neck cancer (HNC). However… 
2013
2013
Interim analysis of the Spanish Lung Cancer Group (SLCG) BRCA1-RAP80 Expression Customization (BREC) randomized phase III trial of customized therapy in advanced non-small cell lung cancer (NSCLC…
LBA8002 Background: Findings from the SLCG phase II customized chemotherapy trial (NCT00883480) showed that RAP80, a component of… 
2011
2011
Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80
DNA double-strand breaks (DSBs) are the most severe type of DNA damage. Occurrence of DSBs in the cell activates the DNA damage… 
2009
2009
Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases
Background Around half of familial breast cancer cases are caused by germ-line mutations in genes which are critically involved… 
2009
2009
The linker connecting the tandem ubiquitin binding domains of RAP80 is critical for lysine 63-linked polyubiquitin-dependent binding activity.
The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a… 
2008
2008
Germline RAP80 mutations and susceptibility to breast cancer
Most of the breast cancer susceptibility genes identified to date are involved in DNA repair, including BRCA1, BRCA2, PALB2… 
2007
2007
Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor α
In this study, we demonstrate that receptor-associated protein 80 (RAP80) interacts with estrogen receptor alpha (ERα) in an… 
2007
2007
RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.
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