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UIMC1 gene

Known as: UBIQUITIN INTERACTION MOTIF-CONTAINING PROTEIN 1, UIMC1, RECEPTOR-ASSOCIATED PROTEIN, 80-KD 
This gene is involved in ubiquitin binding and DNA damage responses.
National Institutes of Health

Related topics

Related topics

5 relations
BRCA1-A Complex Subunit RAP80, humanCell Cycle CheckpointsDNA RepairDouble Strand Break Repair

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Evaluating GWAS-Identified SNPs for Age at Natural Menopause among Chinese Women
Background Age at natural menopause (ANM) is a complex trait with high heritability and is associated with several major hormonal… 
2011
2011
Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine…
2011
2011
Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80
DNA double-strand breaks (DSBs) are the most severe type of DNA damage. Occurrence of DSBs in the cell activates the DNA damage… 
2010
2010
Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families
MERIT40 is a recently identified BRCA1 and RAP80 interacting protein that is essential for protein–protein interactions of a… 
2009
2009
Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases
Background Around half of familial breast cancer cases are caused by germ-line mutations in genes which are critically involved… 
2009
2009
The linker connecting the tandem ubiquitin binding domains of RAP80 is critical for lysine 63-linked polyubiquitin-dependent binding activity.
The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a… 
Review
2008
Review
2008
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.
2008
2008
Germline RAP80 mutations and susceptibility to breast cancer
Most of the breast cancer susceptibility genes identified to date are involved in DNA repair, including BRCA1, BRCA2, PALB2… 
2007
2007
RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.
2007
2007
Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor α
In this study, we demonstrate that receptor-associated protein 80 (RAP80) interacts with estrogen receptor alpha (ERα) in an… 
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