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UGT1A4 gene

Known as: UDP glucuronosyltransferase family 1 member A4, UGT1D, UDP Glucuronosyltransferase 1 Family, Polypeptide A4 Gene 
This gene is involved in xenobiotic metabolism.
National Institutes of Health

Related topics

Related topics

4 relations
UDP-Glucuronosyltransferase 1-4bilirubin glucuronoside glucuronosyltransferaseglycosylationxenobiotic metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity.
2011
2011
Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants
Objectives Olanzapine is an antipsychotic used in the treatment of schizophrenia, bipolar disorder, and treatment-resistant… 
Highly Cited
2010
Highly Cited
2010
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well… 
2010
2010
Serum levels of lamotrigine during delivery in mothers and their infants
2008
2008
Glucuronidation of Monohydroxylated Warfarin Metabolites by Human Liver Microsomes and Human Recombinant UDP-Glucuronosyltransferases
Our understanding of human phase II metabolic pathways which facilitate detoxification and excretion of warfarin (Coumadin) is… 
2007
2007
Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers.
UDP-glucuronosyltransferases (UGTs) catalyze phase-II biotransformation reaction of a variety of substances. Among the UGT1A… 
Highly Cited
2007
Highly Cited
2007
Critical Roles of Residues 36 and 40 in the Phenol and Tertiary Amine Aglycone Substrate Selectivities of UDP-Glucuronosyltransferases 1A3 and 1A4
Despite high sequence identity, UGT1A3 and UGT1A4 differ in terms of substrate selectivity. UGT1A3 glucuronidates the planar… 
Highly Cited
2005
Highly Cited
2005
TRANS-3′-HYDROXYCOTININE O- AND N-GLUCURONIDATIONS IN HUMAN LIVER MICROSOMES
Trans-3′-hydroxycotinine is a major metabolite of nicotine in humans and is mainly excreted as O-glucuronide in smoker's urine… 
Highly Cited
2003
Highly Cited
2003
N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases.
Nicotine is considered the major addictive agent in tobacco. Tobacco users extensively metabolize nicotine to cotinine. Both… 
2002
2002
N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.
N-Glucuronidation in vitro of six 4-arylalkyl-1H-imidazoles (both enantiomers of medetomidine, detomidine, atipamezole, and two… 
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