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Simultaneous determination of antiepileptic drugs and their two active metabolites by HPLC.
An HPLC procedure for the determination of lamotrigine (LAM) simultaneously with other antiepileptic drugs, primidone (PD), phenobarbital (PB), phenytoin (DPH), carbamazepine (CMZ), and two activeExpand
Therapeutic drug monitoring of atypical antipsychotic drugs
Therapeutic drug monitoring (TDM) of antipsychotic drugs is the specific method of clinical pharmacology, which involves measurement of drug serum concentrations followed by interpretation and good cooperation with the clinician. Expand
Evaluation and comparison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods.
The combination of both the specific and non-specific methods for the determination of CyA presents an improved means for the TDM of Cy a and CyA metabolites in renal transplant patients. Expand
Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients.
Both high-flux and low- flux membrane dialysis remove considerable amounts of vancomycin in critically ill septic patients with AKI. Expand
Vancomycin pharmacokinetics during high-volume continuous venovenous hemofiltration in critically ill septic patients.
CVVH at a filtration rate of 45 mL/kg/h leads to high and rapid extracorporeal removal of vancomycin in critically ill patients, and blood sampling is recommended as early as 6 h after first van comycin dose with maintenance dose based on vancomYcin serum level monitoring. Expand
Therapeutic monitoring of amiodarone: pharmacokinetics and evaluation of the relationship between effect and dose/concentration.
The relationship between plasma levels and effect vis á vis the pharmacokinetics and pharmacogenetics of this drug was clarified and certain correlation was seen with oral amiodarone therapy, in others, plasma amiodrone levels were unrelated to therapeutic response and showed no correlation with changes in electrocardiogram or electrophysiological parametres. Expand
Influence of P-glycoprotein on the transplacental passage of cyclosporine.
Findings indicate that P-glycoprotein pumps cyclosporine out of the trophoblast cells of the rat placenta in the ATP-dependent manner and restricts the passage of cyclospora across the placental barrier. Expand
Liquid chromatography-tandem mass spectrometry method for determination of five antidepressants and four atypical antipsychotics and their main metabolites in human serum.
The rapid and simple ultra performance liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous determination parent drugs and their active and nonactive metabolites in human serum and can be successfully applied for routine analyses. Expand
New liquid chromatography-tandem mass spectrometry method for routine TDM of vancomycin in patients with both normal and impaired renal functions and comparison with results of polarization
A new LC-MS/MS method with simple sample extraction and a relatively short period of vancomycin analysis for routine therapeutic drug monitoring was developed and validated and correlated with an FPIA assay (Abbott AxSYM) using mouse monoclonal antibody. Expand
Serum levels of lamotrigine during delivery in mothers and their infants
The data from the large cohort showed the interindividual variability of umbilical cord/maternal serum concentration ratio in lamotrigine monotherapy caused probably by the different activity of the placental lamOTrigine metabolizing enzymes UGT1A4 and 2B7 associated with genetic polymorphism. Expand