xenobiotic metabolism

Known as: xenobiotic metabolic process 
The chemical reactions and physical changes involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e. g… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND The liver is the central organ for xenobiotic metabolism (XM) and is regulated by nuclear receptors such as CAR and… (More)
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Review
2009
Review
2009
The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a… (More)
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Review
2009
Review
2009
Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially genotoxic—epoxides to the corresponding… (More)
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Highly Cited
2007
Highly Cited
2007
Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that contributes to primary metabolism of more… (More)
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Highly Cited
2007
Highly Cited
2007
The glucosylation of pollutant and pesticide metabolites in plants controls their bioactivity and the formation of subsequent… (More)
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Highly Cited
2007
Highly Cited
2007
Our previous microarray expression analysis of the long-lived Little mice (Ghrhr(lit/lit)) showed a concerted up-regulation of… (More)
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Highly Cited
2006
Highly Cited
2006
While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in… (More)
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Review
2004
Review
2004
The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode… (More)
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Review
1998
Review
1998
Sex-dependent differences in xenobiotic metabolism have been most extensively studied in the rat. Because sex-dependent… (More)
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Highly Cited
1997
Highly Cited
1997
Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and… (More)
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