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U 74500A

Known as: Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, hydrochloride, (16alpha)-, U-74500A, U74500A 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Anti-Ulcer AgentAntioxidantsImmunosuppressive AgentsPregnatrienes
U 74500EU74500

Papers overview

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2000
2000
Small oxidative changes in atherogenic LDL concentrations irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A.
1998
1998
Cardioprotective effects of pinacidil pretreatment and lazaroid (U74500A) preservation in isolated rat hearts after 12-hour hypothermic storage.
BACKGROUND Two important processes in the preservation of the function of donor hearts are the maintenance of ATP-sensitive… 
1996
1996
The effect of lazaroid (U74500A), a novel inhibitor of lipid peroxidation, on 24-hour heart preservation. A study based on a working model using cross-circulated blood-perfused rabbit hearts.
Lazaroid, an inhibitor of iron-mediated lipid peroxidation, has been shown to reduce free radical-mediated injury after ischemia… 
1996
1996
Successful twenty-four-hour canine lung preservation with lazaroid U74500A.
BACKGROUND Lipid peroxidation is known to contribute to ischemia-reperfusion injury. U74500A is a 21-aminosteroid (lazaroid) that… 
1995
1995
Traumatic neuronal injury in cortical cell culture is attenuated by 21-aminosteroids
1995
1995
Hemin toxicity in a human epithelioid sarcoma cell line.
The major cytotoxic component of hemin was identified as metal free protoporphyrin IX in an epithelioid sarcoma cell line (VA-ES… 
Highly Cited
1994
Highly Cited
1994
SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant.
1994
1994
Role of lipid mediators in the pathogenesis of skeletal muscle infarction and oedema during reperfusion after ischaemia
During revascularization of skeletal muscle lipid mediators are released that may have a role in the pathogenesis of reperfusion… 
1992
1992
Antiproliferative properties of aminosteroid antioxidants on cultured cancer cells.
1990
1990
Heme uptake by endothelium synergizes polymorphonuclear granulocyte-mediated damage.
Transitional metals, particularly iron, markedly potentiate oxidant damage to isolated cell organelles. However, determining the… 
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