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U-50488

Known as: U 50,488H, U 50488H, U-50,488H 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Following series of synthetic cannabinoid and synthetic cathinone derivatives, the illicit drug market has begun to see increased… Expand
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Highly Cited
2007
Highly Cited
2007
The molecular mechanisms mediating stress-induced dysphoria in humans and conditioned place aversion in rodents are unknown. Here… Expand
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Highly Cited
2005
Highly Cited
2005
RationaleStress and depression have been linked to relapse of cocaine abuse. Antagonism of the kappa opioid receptor (KOR) has… Expand
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Highly Cited
1998
Highly Cited
1998
***micro***-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong… Expand
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Highly Cited
1998
Highly Cited
1998
The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Noxious cutaneous stimuli enhance spinal excitability. The behavioral correlate to this response is found in the rat… Expand
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Highly Cited
1989
Highly Cited
1989
This study examined a possible peripheral site of action of opioids in the modulation of the response to noxious pressure on… Expand
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Highly Cited
1988
Highly Cited
1988
Previously, we reported on an opioid antagonist, nor-binaltorphimine (nor-BNI), that had high selectivity for kappa opioid… Expand
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Highly Cited
1984
Highly Cited
1984
The intrathecal administration of mu (morphine) and delta (D-Ala2-D-Leu5-enkephalin) but not kappa agonists (ethylketocyclazocine… Expand
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Highly Cited
1984
Highly Cited
1984
The opioid receptors involved in the mediation of thermal analgesia (55 degrees C hot-plate) and inhibition of gastrointestinal… Expand
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