U-50488

Known as: U 50,488H, U 50488H, U-50,488H 
 

Topic mentions per year

Topic mentions per year

1982-2018
020406019822018

Papers overview

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Highly Cited
2007
Highly Cited
2007
The molecular mechanisms mediating stress-induced dysphoria in humans and conditioned place aversion in rodents are unknown. Here… (More)
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Highly Cited
2005
Highly Cited
2005
Stress and depression have been linked to relapse of cocaine abuse. Antagonism of the kappa opioid receptor (KOR) has been… (More)
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Highly Cited
1998
Highly Cited
1998
***micro***-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong… (More)
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Highly Cited
1997
Highly Cited
1997
Previous studies have indicated that central opioid peptides and opiate receptors play an important role in the modulation of… (More)
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Highly Cited
1993
Highly Cited
1993
An unbiased conditioned place preference paradigm was used to examine the neuroanatomical substrates mediating the reinforcing… (More)
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Highly Cited
1993
Highly Cited
1993
In vivo microdialysis was used to assess the involvement of ventral tegmental area (VTA) mu, delta, and kappa opioid receptors in… (More)
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Highly Cited
1992
Highly Cited
1992
The kappa-receptor selectivity of nor-binaltorphimine (nor-BNI), a highly selective kappa-opioid receptor antagonist in vitro… (More)
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Highly Cited
1989
Highly Cited
1989
This study examined a possible peripheral site of action of opioids in the modulation of the response to noxious pressure on… (More)
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Highly Cited
1988
Highly Cited
1988
Previously, we reported on an opioid antagonist, nor-binaltorphimine (nor-BNI), that had high selectivity for kappa opioid… (More)
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1985
1985
U-50488 [trans-3,4-dichloro-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide] is a structurally novel analgesic reported to have… (More)
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