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Curcumin Therapy in Inflammatory Bowel Disease: A Pilot Study
Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was… Expand
Hepatobiliary complications of total parenteral nutrition.
Inducing positive nitrogen balance and weight gain in patients fed exclusively parenterally was documented first by Dudrick et al. in 1968. Since that time, total parenteral nutrition (TPN) has… Expand
An update on the use and investigation of probiotics in health and disease
Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal… Expand
Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac.
BACKGROUND & AIMS 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (HRIs) were found incidentally to reduce new cases of colon cancer in 2 large clinical trials evaluating… Expand
Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis.
BACKGROUND & AIMS Cyclin D1 gene amplification and/or overexpression occurs in several human cancers. The level of expression of cyclin D1 protein during the multistage process of human colon… Expand
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.
- M. Krajewska, S. Moss, S. Krajewski, K. Song, P. Holt, John Calvin Reed
- Cancer research
- 15 May 1996
Expression of several members of the BCL-2 family of genes was investigated by immunohistochemical methods in 30 primary colorectal adenocarcinomas and 24 adenomatous polyps. When compared to the… Expand
Induction of gastric epithelial apoptosis by Helicobacter pylori.
BACKGROUND--Helicobacter pylori may promote gastric carcinogenesis through increasing gastric epithelial cell proliferation. How H pylori does so is unknown. Programmed, non-necrotic, cell death… Expand
Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis.
- S. Pendyala, L. Neff, M. Suárez-Fariñas, P. Holt
- Biology, Medicine
- The American journal of clinical nutrition
- 1 February 2011
BACKGROUND Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic… Expand
A high-fat diet is associated with endotoxemia that originates from the gut.
Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome. Placing 8 healthy subjects on a… Expand
Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide.
Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced incidence of colon cancer in various human populations. Experimental carcinogenesis studies in animal models… Expand