P. Barnes

Publications2,202
h-index202
Citations179,631
Highly Influential Citations5,771
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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
TLDR
It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
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Global strategy for asthma management and prevention: GINA executive summary
TLDR
It is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained, and the Global Initiative for Asthma recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions.
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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of…
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Immunology of asthma and chronic obstructive pulmonary disease
  • P. Barnes
  • Medicine, Biology
    Nature Reviews Immunology
  • 15 February 2008
TLDR
It is now becoming clear that the distinction between these diseases becomes blurred in patients with severe asthma, in asthmatic subjects who smoke and during acute exacerbations, which has important implications for the development of new therapies.
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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary.
TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of deescalation of therapy is introduced in the treatment assessment scheme.
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Exhaled breath condensate: methodological recommendations and unresolved questions
TLDR
The aim of the American Thoracic Society/European Respiratory Society Task Force on EBC was to identify the important methodological issues surrounding EBC collection and assay, to provide recommendations for the measurements and to highlight areas where further research is required.
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Systemic manifestations and comorbidities of COPD
TLDR
Treatment of COPD inflammation may concomitantly treat systemic inflammation and associated comorbidities, however, new broad-spectrum anti-inflammatory treatments, such as phosphodiesterase 4 inhibitors, have significant side-effects so it may be necessary to develop inhaled drugs in the future.
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Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.
TLDR
A significant increase in neutrophils and increased concentrations of tumor necrosis factor-alpha (TNF alpha) and interleukin-8 (IL-8) in the patients with COPD compared with the smoking and nonsmoking control subjects means that the cytokines TNF alpha and IL-8 may be involved in the inflammation in COPD.
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Anti-inflammatory actions of glucocorticoids: molecular mechanisms.
  • P. Barnes
  • Biology, Medicine
    Clinical science
  • 1 June 1998
TLDR
This new understanding of glucocorticoid mechanisms may lead to the development of novel steroids with less risk of side effects (which are due to the endocrine and metabolic actions of steroids), and 'Dissociated' steroids which are more active in transrepression than transactivation (GRE binding) have now been developed.
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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019
TLDR
Blood eosinophils are recommended as a biomarker to support clinical decisions regarding the use of inhaled corticosteroids in chronic obstructive pulmonary disease patients, based on recent evidence from clinical trials.
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