ERS guidelines on the assessment of cough
- A. Morice, G. Fontana, J. Widdicombe
- MedicineEuropean Respiratory Journal
- 1 June 2007
Cough can have profound effects on health status, which can be assessed by cough-specific health status questionnaires, and may be used to follow change in cough reflex sensitivity in an individual.
Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking.
- N. Shenker, S. Polidoro, J. Flanagan
- Biology, MedicineHuman Molecular Genetics
- 1 March 2013
The data show that smoking has a direct effect on the epigenome in lung tissue, which is also detectable in peripheral blood DNA and may contribute to cancer risk.
Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium
- L. Slater, N. Bartlett, M. Edwards
- Biology, MedicinePLoS Pathogens
- 1 November 2010
Anti-viral defense within bronchial epithelium requires co-ordinated recognition of rhinovirus infection, initially via TLR3/TRIF and later via inducible RNA helicases.
Lung-resident eosinophils represent a distinct regulatory eosinophil subset.
- Claire Mesnil, Stéfanie Raulier, F. Bureau
- Biology, MedicineJournal of Clinical Investigation
- 1 September 2016
It is reported that steady-state pulmonary rEos are IL-5-independent parenchymal Siglec-FintCD62L+CD101lo cells with a ring-shaped nucleus, which defines lung rEOS as a distinct eosinophil subset with key homeostatic functions.
Nitric oxide and lung disease.
- P. Barnes, M. Belvisi
- BiologyThorax
- 1 October 1993
There has been an explosion of information about nitric oxide which appears to be involved in an extraordinary range of functions including vascular regulation, neurotransmission, host defence, and cytotoxicity.
Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
- J. Mitchell, M. Belvisi, J. Vane
- Biology, MedicineBritish Journal of Pharmacology
- 1 November 1994
Results show that COX‐2 expression correlates with the exaggerated release of prostaglandins from cytokine‐activated epithelial cells and that the induction of the enzyme is suppressed by glucocorticosteroid.
Release of granulocyte‐macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone
- M. Saunders, J. Mitchell, M. Belvisi
- Biology, MedicineBritish Journal of Pharmacology
- 1 February 1997
The data suggest that human airway smooth muscle cells might play an active part in initiating and/or perpetuating airway inflammation in addition to controlling airway calibre.
Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease
- M. Edwards, N. Bartlett, D. Clarke, M. Birrell, M. Belvisi, S. Johnston
- Biology, MedicinePharmacology and Therapeutics
- 6 October 2008
TRPA1 agonists evoke coughing in guinea pig and human volunteers.
- M. Birrell, M. Belvisi, A. Morice
- BiologyAmerican Journal of Respiratory and Critical Care…
- 1 December 2009
This study identifies the TRPA1 receptor as a promiscuous receptor, activated by a wide range of stimuli, making it a perfect target for triggering cough and as such one of the most promising targets currently identified for the development of antitussive drugs.
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids
- S. Moschos, A. Williams, M. Perry, M. Birrell, M. Belvisi, M. Lindsay
- Biology, MedicineBMC Genomics
- 17 July 2007
It is shown that the LPS-induced innate immune response is associated with widespread, rapid and transient increases in miRNA expression in the mouse lung and it is speculated that these changes might be involved in the regulation of the inflammatory response.
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