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U 0521

Known as: 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone, U-0521, U0521 
National Institutes of Health

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Broader (1)

Propiophenones

Papers overview

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2005
2005
The influence of block of catechol-O-methyl transferase on the sensitivity of isolated organs to catecholamines
SummaryThe sensitivity of various isolated organs to catecholamines was tested before and after block of catechol-O-methyl… 
Highly Cited
2004
Highly Cited
2004
Extraneuronal removal, accumulation and O-methylation of isoprenaline in the perfused heart
Summary1.Isolated rat and guinea-pig hearts were perfused with 0.95 μM (±)-isoprenaline or 3H(±)-isoprenaline, a catecholamine… 
2004
2004
The distribution of 3H-(±)noradrenaline in rabbit aortic strips after inhibition of the noradrenaline-metabolizing enzymes
SummaryRabbit aortic strips (nerve-free, reserpinepretreated or normal) whose noradrenaline-metabolizing enzymes were inhibited… 
2004
2004
The relaxation of rabbit aortic strips after a preceding exposure to sympathomimetic amines
SummaryRabbit aortic strips were exposed to various sympathomimetic amines; after wash out of the amines the relaxation of the… 
2004
2004
Stereoselectivity of the distribution of labelled noradrenaline in rabbit aortic strips after inhibition of the noradrenaline-metabolizing enzymes
SummaryRabbit aortic strips (nerv--free, reserpinepretreated or normal) whose noradrenaline-metabolizing enzymes were inhibited… 
1987
1987
Metabolism of [3H]2-hydroxyestradiol by cultured porcine granulosa cells: evidence for the presence of a catechol-O-methyltransferase pathway and a direct stimulatory effect of 2-methoxyestradiol on…
Porcine granulosa cells synthesize and respond to catecholestrogens, but the stimulatory potency of catecholestrogens on… 
1978
1978
The influence of monoamine oxidase and catechol-O-methyl transferase on the distribution of 3H-(±)-noradrenaline in rabbit aortic strips
Summary1.Rabbit aortic strips were incubated with 1.18 μM 3H-(±)-noradrenaline for 30 min, and the accumulation of noradrenaline… 
1977
1977
Activation of myocardial β-adrenoceptors by the nitrogen-free low affinity ligand 3′,4′-dihydroxy-α-methylpropiophenone (U-0521)
SummaryThe effect of 3′,4′-dihydroxy-α-methylpropiophenone (U-0521) on the rate of spontaneously contracting cultured rat heart… 
1977
1977
Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521).
The effect of 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521) on the rate of spontaneously contracting cultured rat heart… 
1975
1975
Supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-O-methyl transferase.
In cat papillary muscle and nictitating membrane block of extraneuronal catechol-O-methyl transferase (COMT) by 3',4'-dihydroxy…