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U 0521

Known as: 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone, U-0521, U0521 
National Institutes of Health

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1 relation

Broader (1)

Propiophenones

Papers overview

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2004
2004
The distribution of 3H-(±)noradrenaline in rabbit aortic strips after inhibition of the noradrenaline-metabolizing enzymes
SummaryRabbit aortic strips (nerve-free, reserpinepretreated or normal) whose noradrenaline-metabolizing enzymes were inhibited… 
Highly Cited
2004
Highly Cited
2004
Extraneuronal removal, accumulation and O-methylation of isoprenaline in the perfused heart
Summary1.Isolated rat and guinea-pig hearts were perfused with 0.95 μM (±)-isoprenaline or 3H(±)-isoprenaline, a catecholamine… 
Highly Cited
2004
Highly Cited
2004
Analysis of the compartments involved in the extraneuronal storage and metabolism of isoprenaline in the perfused heart
Summary1.Rat hearts were perfused with various concentrations of 3H-(±)-isoprenaline, and initial rates were determined for the… 
1999
1999
Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters.
The aims of this study were to characterize the recently cloned rat norepinephrine transporter (NET) in more detail and in… 
1983
1983
A comparative study of the properties of the catechol-O-methyltransferase inhibitors, U-0521 and tropolone acetamide, in rat perfused heart
SummaryThe properties of two inhibitors of catechol-O-methyltransferase (COMT), U-0521 and tropolone acetamide, were compared in… 
1983
1983
Effect of steroids on beta-adrenoceptor-mediated relaxation of pig bronchus.
1--Progesterone, testosterone (40 microM), cortisol and cortisol hemisuccinate (80 microM) caused 6-8 fold potentiations of… 
1981
1981
Modulation of slow postsynaptic potentials by dopamine, in rabbit sympathetic ganglion
1979
1979
EFFECTS OF UPTAKE INHIBITORS ON RESPONSES OF SHEEP CORONARY ARTERIES TO CATECHOLAMINES AND SYMPATHETIC NERVE STIMULATION
1 Transmural stimulation of intrinsic sympathetic nerves and exogenous catecholamines produce β1‐adrenoceptor mediated relaxant… 
1967
1967
Studies on the potentiation of the inotropic actions of certain catecholamines by U-0521 (3',4'-dihydroxy-alpha-methyl propiophenone).
A competitive inhibitor of catechol-O-methyl transferase (COMT), 39,49-dihydroxy-α-methyl propiophenone (U-0521), was found to… 
1967
1967
The catechol-O-methyl transferase activity and endogenous catecholamine content of various tissues in the rat and the effect of administration of U-0521 (3',4'-dihydroxy-2-methyl propiophenone).
The regulatory influence of COMT (catechol-O-methyl transferase) on the catecholamine content of various tissues was investigated… 
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