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Preferential metabolism of (—)-3H-norepinephrine through the deaminated glycol in the rat vas deferens
Abstract A method for separation of norepinephrine (NE) and its metabolites by the combined use of Alumina and Dowex columns is described. The most commonly used eluents, 0·2 N acetic acid, 0·04 N…
Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers
- W. Wingender, K. Graefe, W. Gau, D. Förster, D. Beermann, P. Schacht
- MedicineEuropean Journal of Clinical Microbiology
- 1 August 1984
The pharmacokinetics of ciprofloxacin (Bay o 9867) was examined after a single oral dose of 250 mg and a single intravenous dose of 100 mg respectively in six healthy male volunteers in an open,…
The Transport of Amines Across the Axonal Membranes of Noradrenergic and Dopaminergic Neurones
In contrast to acetylcholine, which is removed at cholinergic junctions by enzymic degradation, the transmitter noradrenaline is primarily inactivated by membrane transport. Two membrane transport…
The effect of hydrocortisone on the sensitivity of the isolated nictitating membrane to catecholamines
- K. Graefe, U. Trendelenburg
- Chemistry, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 March 1974
The sensitivity experiments are consistent with the existence of a quickly equilibrating, extraneuronal O-methylating compartment with high affinity for catecholamines; it has a saturable, hydrocortisone-sensitive uptake mechanism and little or no capacity for storage of unchanged catechlamine.
Roles of uptake1 and catechol-O-methyltransferase in removal of circulating catecholamines in the rabbit.
- B. Friedgen, T. Halbrügge, K. Graefe
- Chemistry, MedicineThe American journal of physiology
- 1 December 1994
Comparison of the desipramine-sensitive components of ERS and ERP indicated that for uptake1 NE was the preferred substrate in the systemic circulation and DA was preferred in the pulmonary circulation.
Pharmacokinetics and metabolism of calcium-blocking agents nifedipine, nitrendipine, and nimodipine.
Assay of catecholamines and dihydroxyphenylethyleneglycol in human plasma and its application in orthostasis and mental stress.
The simultaneous measurement of plasma NA and DOPEG may help to distinguish between various types of activation of the sympathetic nervous system.
Inhibition of gastric secretion in man by rioprostil, a new synthetic methyl prostaglandin E1.
It is concluded that rioprostil is a potent inhibitor of both acid and pepsin secretion in man.
Neuronal and extraneuronal uptake and metabolism of catecholamines.
Effects of N‐ethylmaleimide on 5‐hydroxytryptamine transport and sodium content in rabbit platelets
NEM inhibits 5‐HT transport by inhibiting the Na+/K+‐ATPase and not by a direct interaction with the5‐HT carrier, which hinders 5‐ HT inward transport.