Comparison of post-junctional α-adrenoceptors in iris dilator muscle of humans, and albino and pigmented rabbits

@article{Ishikawa2004ComparisonOP,
  title={Comparison of post-junctional $\alpha$-adrenoceptors in iris dilator muscle of humans, and albino and pigmented rabbits},
  author={Hitoshi Ishikawa and Popat N. Patil and Duane D. Miller},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={354},
  pages={765-772}
}
The relative potency of α-adrenoceptor agonists and the dissociation constants of competitive antagonists were studied to characterize the post junctional α-adrenoceptor of the human iris dilator muscle. The data obtained from human iris dilator tissue was compared to that from rabbit. The iris dilator muscle was mounted in an organ bath and tension changes were recorded. (−)-Norepinephrine, (−)-phenylephrine (PE), oxymetazoline and p-aminoclonidine caused contractile responses in albino rabbit… Expand
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